Evidence map›Paper›PMID 39043745›Full record

ArticleScientific reports2024

Discovery of anti-Mycobacterium tuberculosis desertomycins from Streptomyces flavofungini TRM90047 based on genome mining and HSQC-TOCSY.

Lei Wang, Aikebaier Reheman, Chuanxing Wan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lei WangState Key Laboratory Breeding Base for The Protection and Utilization of Biological Resources in TarimBasin Co-Funded By Xinjiang Production & Construction Corps and The Ministry of Science & Technology / College of Life Science and Technology, Tarim University, Alar, 843300, China.
Aikebaier RehemanCollege of Animal Science and Technology, Tarim University, Alar, 843300, China.
Chuanxing WanState Key Laboratory Breeding Base for The Protection and Utilization of Biological Resources in TarimBasin Co-Funded By Xinjiang Production & Construction Corps and The Ministry of Science & Technology / College of Life Science and Technology, Tarim University, Alar, 843300, China. wanchuanxing@163.com.

Funding

Autonomous Region Graduate Research Innovation Project，XinJiang, China XJ2021G29National Natural Science Foundation of China 32060023The Third Xinjiang Scientific Expedition Program, China 2022xjkk0200
6 · The paper itself

Abstract

Tuberculosis caused by Mycobacterium tuberculosis (M. tb) is a major public health problem with high morbidity and mortality worldwide. In our previous study, we found that a fermentation product of Streptomyces flavofungini TRM90047 exhibited anti-M. tb activity and decreased the expression level of several genes, including rpsL, Rplc and ClpC1. Guided by heteronuclear single quantum correlation-total correlation spectroscopy (HSQC-TOCSY) fingerprints and genome mining, we isolated two new 44-membered macrolides, desertomycin 44-1 (1) and desertomycin 44-2 (2), together with known desertomycin A (3) from S. flavofungini TRM90047. Three desertomycins showed anti-M. tb activity. The EC

Indexed as

Antitubercular AgentsMolecular Docking SimulationMycobacterium tuberculosisStreptomycesBacterial ProteinsGenome, BacterialMacrolidesMicrobial Sensitivity TestsAntitubercular AgentsBacterial ProteinsMacrolidesAnti-M. tbDesertomycinGenome miningHSQC-TOCSY

Identifiers

PMID39043745
PMCPMC11266358

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.