Evidence map›Paper›PMID 39043726›Full record

ArticleScientific reports2024

Ameliorative effects of sildenafil against carbon tetrachloride induced hepatic fibrosis in rat model through downregulation of osteopontin gene expression.

Hend Elsayed Nasr, Ahmed Medhat Hegazy, Noha Osama El-Shaer, Rabab Shaban El-Shafey, Salwa A Elgendy, Heba A Elnoury, Walaa Bayoumie El Gazzar, Lina Abdelhady Mohammed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hend Elsayed NasrDepartment of Medical Biochemistery and Molecular Biology, Faculty of Medicine, Benha University, Benha, 13518, Egypt.
Ahmed Medhat HegazyDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, 13736, Qalyubia, Egypt. ahmed_medhat012@yahoo.com.ORCID 0000-0001-8606-5937
Noha Osama El-ShaerDepartment of Physiology, Faculty of Medicine, Benha University, Benha, 13518, Egypt.
Rabab Shaban El-ShafeyDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha, 13518, Egypt.
Salwa A ElgendyDeparment of Pharmacology, Faculty of Medicine, Benha University, Benha, 13518, Egypt.
Heba A ElnouryDeparment of Pharmacology, Faculty of Medicine, Benha University, Benha, 13518, Egypt.
Walaa Bayoumie El GazzarDepartment of Medical Biochemistery and Molecular Biology, Faculty of Medicine, Benha University, Benha, 13518, Egypt.
Lina Abdelhady MohammedDepartment of Medical Biochemistery and Molecular Biology, Faculty of Medicine, Benha University, Benha, 13518, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The liver carries out many essential tasks, such as synthesising cholesterol, controlling the body's storage of glycogen, and detoxifying metabolites, in addition to performing, and regulating homeostasis. Hepatic fibrosis is a pathological state characterized by over accumulation of extracellular matrix (ECM) including collagen fibers. Sildenafil (a selective inhibitor of type 5 phosphodiesterase) has anti-inflammatory, antioxidant and anti-apoptotic properties. It is commonly used to treat erectile dysfunction in male. The purpose of the current investigation was to evaluate sildenafil's hepatoprotective potential against liver fibrosis in rats that was caused by carbon tetrachloride (CCl

Indexed as

Carbon TetrachlorideLiver CirrhosisOsteopontinSildenafil CitrateAnimalsAntioxidantsDisease Models, AnimalDown-RegulationGene Expression RegulationLiverMaleOxidative StressRatsRats, WistarAntioxidantsCarbon TetrachlorideOsteopontinSildenafil CitrateCarbon tetrachlorideHepatoprotectiveOsteopontinOxidative markersSildenafil

Identifiers

PMID39043726
PMCPMC11266717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.