ReviewEmerging infectious diseases2024
Outbreak of Intermediate Species Leptospira venezuelensis Spread by Rodents to Cows and Humans in L. interrogans-Endemic Region, Venezuela.
Review in Emerging infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A systematic review ofOne health (Amsterdam, Netherlands) · 2026Article
- Novel Target for Pathogenic Leptospira Detection via Colorimetric Loop-Mediated Isothermal Amplification (LAMP): Development, Validation, and Comparative Analysis.Journal of clinical laboratory analysis · 2026Article
- Genetic Epidemiology of Bovine Leptospirosis: A Global Perspective from Sequence and Genome Datasets.Animals : an open access journal from MDPI · 2026Article
- Diagnostic Performance of Two Commercial qPCR Kits forTropical medicine and infectious disease · 2026Article
- Molecular epidemiology of rodent-borneJournal of medical microbiology · 2026Article
- Leptospira interrogans HtrA protease is a potent inducer of multifaceted cellular responses.Antonie van Leeuwenhoek · 2026Article
- Laboratory Diagnosis of Leptospirosis.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Genomic and ecological systems-thinking framework for pathogenicFrontiers in public health · 2026Article
- Detection of P1 and P2 Subclades of Leptospira carriage in swine in Sri Lanka.BMC veterinary research · 2025Article
- Endemicity, Clinical Features, Risk Factors, and the Potential for Severe Infection inTropical medicine and infectious disease · 2025Article
- Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis.Emerging infectious diseases · 2025Article
- Design and set-up of the leptospirosis registryFrontiers in public health · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptospirosis is a common but underdiagnosed zoonosis. We conducted a 1-year prospective study in La Guaira State, Venezuela, analyzing 71 hospitalized patients who had possible leptospirosis and sampling local rodents and dairy cows. Leptospira rrs gene PCR test results were positive in blood or urine samples from 37/71 patients. Leptospira spp. were isolated from cultured blood or urine samples of 36/71 patients; 29 had L. interrogans, 3 L. noguchii, and 4 L. venezuelensis. Conjunctival suffusion was the most distinguishing clinical sign, many patients had liver involvement, and 8/30 patients with L. interrogans infections died. The Leptospira spp. found in humans were also isolated from local rodents; L. interrogans and L. venezuelensis were isolated from cows on a nearby, rodent-infested farm. Phylogenetic clustering of L. venezuelensis isolates suggested a recently expanded outbreak strain spread by rodents. Increased awareness of leptospirosis prevalence and rapid diagnostic tests are needed to improve patient outcomes.
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