Evidence map›Paper›PMID 39042709›Full record

ArticleACS biomaterials science & engineering2024

Elemental and Structural Characterization of Heterotopic Ossification during Achilles Tendon Healing Provides New Insights on the Formation Process.

Kunal Sharma, Isabella Silva Barreto, Hector Dejea, Malin Hammerman, Christian Appel, Kalotina Geraki, Pernilla Eliasson, Maria Pierantoni, Hanna Isaksson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Piezo2FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kunal SharmaDepartment of Biomedical Engineering, Lund University, Box 118, 221 00 Lund, Sweden.ORCID 0000-0003-3063-3709
Isabella Silva BarretoDepartment of Biomedical Engineering, Lund University, Box 118, 221 00 Lund, Sweden.ORCID 0000-0002-9413-8320
Hector DejeaDepartment of Biomedical Engineering, Lund University, Box 118, 221 00 Lund, Sweden.
Malin HammermanDepartment of Biomedical Engineering, Lund University, Box 118, 221 00 Lund, Sweden.
Christian AppelSwiss Light Source, Paul Scherrer Institute, CH-5232 Villigen, Switzerland.
Kalotina GerakiDiamond Light Source, Oxfordshire OX11 0DE, United Kingdom.
Pernilla EliassonDepartment of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden.
Maria PierantoniDepartment of Biomedical Engineering, Lund University, Box 118, 221 00 Lund, Sweden.
Hanna IsakssonDepartment of Biomedical Engineering, Lund University, Box 118, 221 00 Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterotopic ossification (HO) in tendons can lead to increased pain and poor tendon function. Although it is believed to share some characteristics with bone, the structural and elemental compositions of HO deposits have not been fully elucidated. This study utilizes a multimodal and multiscale approach for structural and elemental characterization of HO deposits in healing rat Achilles tendons at 3, 6, 12, 16, and 20 weeks post transection. The microscale tomography and scanning electron microscopy results indicate increased mineral density and Ca/P ratio in the maturing HO deposits (12 and 20 weeks), when compared to the early time points (3 weeks). Visually, the mature HO deposits present microstructures similar to calcaneal bone. Through synchrotron-based X-ray scattering and fluorescence, the hydroxyapatite (HA) crystallites are shorter along the

Indexed as

Achilles TendonOssification, HeterotopicAnimalsCalciumDurapatiteMaleRatsRats, Sprague-DawleyWound HealingCalciumDurapatitesmall-angle X-ray scatteringsmall animal modeltissue characterizationwide-angle X-ray scatteringX-ray fluorescence

Identifiers

PMID39042709
PMCPMC11322912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.