Evidence map›Paper›PMID 39042440›Full record

ArticleeLife2024

Aberrant hippocampal Ca

Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O'Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck and 2 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Nicola MasalaUniversity of Bonn, Faculty of Medicine, Institute for Experimental Epileptology and Cognition Research (IEECR), Bonn, Germany.
Manuel MittagNeuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Eleonora Ambrad GiovannettiNeuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Darik A O'NeilNeuroTechnology Center, Columbia University, New York, United States.
Fabian J DistlerUniversity of Bonn, Faculty of Medicine, Institute for Experimental Epileptology and Cognition Research (IEECR), Bonn, Germany.
Peter RupprechtBrain Research Institute, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-8235-8257
Fritjof HelmchenBrain Research Institute, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-8867-9569
Rafael YusteNeuroTechnology Center, Columbia University, New York, United States.ORCID https://orcid.org/0000-0003-4206-497X
Martin FuhrmannNeuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID https://orcid.org/0000-0001-7672-2913
Heinz BeckUniversity of Bonn, Faculty of Medicine, Institute for Experimental Epileptology and Cognition Research (IEECR), Bonn, Germany.ORCID https://orcid.org/0000-0002-8961-998X
Michael WenzelUniversity of Bonn, Faculty of Medicine, Institute for Experimental Epileptology and Cognition Research (IEECR), Bonn, Germany.ORCID https://orcid.org/0000-0002-6065-1660
Tony KellyUniversity of Bonn, Faculty of Medicine, Institute for Experimental Epileptology and Cognition Research (IEECR), Bonn, Germany.ORCID https://orcid.org/0000-0001-6066-0455

Funding

Reexamining the Role of Dendrites in Neuronal FunctionRM1NS132981 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Jayeeta Basu, RAFAEL YUSTE · 2023 to 2026
$10.3M
Effect of GABAergic inhibition of dendritic spines on synaptic pruning in the medial prefrontal cortex during adolescenceR01MH115900 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI SMITH, SHERYL S · 2019 to 2023
$3.2M
The Neglected Subiculum: Decoding and Manipulating Memory Retrieval with Multiphoton HolographyF99NS134209 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI O'NEIL, DARIK ANDREW · 2023 to 2024
$99k
Deutsche Forschungsgemeinschaft BE 1822/13-1Deutsche Forschungsgemeinschaft FOR-2715Deutsche Forschungsgemeinschaft SFB1089Deutsche Forschungsgemeinschaft SPP2395NIMH NIH HHS R01 MH115900NINDS NIH HHS F99 NS134209NINDS NIH HHS RM1 NS132981
6 · The paper itself

Abstract

Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using optical imaging. The viral transduction of GECIs is commonly used to target expression to specific brain regions, can be conveniently used with any mouse strain of interest without the need for prior crossing with a GECI mouse line, and avoids potential hazards due to the chronic expression of GECIs during development. A key requirement for monitoring neuronal activity with an indicator is that the indicator itself minimally affects activity. Here, using common adeno-associated viral (AAV) transduction procedures, we describe spatially confined aberrant Ca

Indexed as

CalciumDependovirusHippocampusSynapsinsAnimalsGenetic VectorsMaleMiceMice, Inbred C57BLPromoter Regions, GeneticTransduction, GeneticCalciumSynapsinsAAVGCaMPGECIin vivomouseneuroscience

Identifiers

PMID39042440
PMCPMC11265795

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.