Evidence map›Paper›PMID 39042316›Full record

Trial reportArchives of dermatological research2024

The effect of histopathologic analysis and tissue cultures on inpatient management of cellulitis: a randomized control trial.

Michael Lause, Emma Hansen, Karissa Libson, Cory Pettit, Sonia Himed, Kyle P Rismiller, Sara Huff, Abraham M Korman, Alecia M Blaszczak, Willa Hsueh and 9 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Michael LauseDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Emma HansenCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Karissa LibsonCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Cory PettitDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Sonia HimedDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kyle P RismillerDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Sara HuffDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Abraham M KormanDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Alecia M BlaszczakCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Willa HsuehCollege of Medicine, The Ohio State University, Columbus, OH, USA.
Nima Milani-NejadDepartment of Dermatology, University of California Los Angeles, Los Angeles, CA, USA.
Leah KofmehlDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Courtney HebertDepartment of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Jeffrey M CaterinoDepartment of Emergency Medicine, The Ohio State University, Columbus, OH, USA.
Henry E WangDepartment of Emergency Medicine, The Ohio State University, Columbus, OH, USA.
Vedat YildizDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
John C TrinidadDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Catherine G ChungDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Benjamin H KaffenbergerDepartment of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Benjamin.kaffenberger@osumc.edu.

Funding

The Center for Clinical and Translational Science at The Ohio State University Wexner Medical Center Patient Safety Advancement Grant
6 · The paper itself

Abstract

backgroundIn the absence of a gold-standard diagnostic modality for cellulitis, sterile inflammatory disorders may be misdiagnosed as cellulitis.

objectiveTo determine the utility of skin biopsy and tissue culture for the diagnosis and management of patients admitted with a diagnosis of presumed cellulitis.

designPilot single-blind parallel group randomized controlled clinical trial in 56 patients with a primary diagnosis of presumed cellulitis. In the intervention group only, skin biopsy and tissue culture results were made available to the primary care team to guide diagnosis and management. Length of hospital stay and antibiotic use were evaluated as outcome measures.

resultsLength of stay showed the greatest opportunity for further study as a primary outcome (intervention: 4, IQR (2-6) vs. control: 5 IQR (3-8) days; p = 0.124). LIMITATIONS: The COVID-19 pandemic placed limitations on participant enrollment and study duration; in addition, data was collected from a single medical center.

conclusionThis study demonstrates that length of stay and anti-pseudomonal antibiotic de-escalation are endpoints that may be influenced by biopsy and tissue culture results in presumed cellulitis patients; these outcomes warrant further study.

Indexed as

Anti-Bacterial AgentsCellulitisCOVID-19Length of StayAdultAgedBiopsyFemaleHumansInpatientsMaleMiddle AgedPilot ProjectsSARS-CoV-2Single-Blind MethodSkinAnti-Bacterial AgentsAnalysisBiopsyCellulitisCultureHistopathologicInpatientManagementPseudocellulitisTissue

Identifiers

PMID39042316
PMCPMC11266447

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.