Evidence map›Paper›PMID 39042244›Full record

ArticleDrug delivery and translational research2024

Blood vessel wall shear stress determines regions of liposome accumulation in angiogenic vasculature.

M Juliana Gomez-Garcia, Mahmoud Abdelkarim, David T Cramb, Sarah J Childs, Kristina D Rinker, Hagar I Labouta

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M Juliana Gomez-GarciaBiomedical Engineering, Faculty of Engineering, University of Toronto, Toronto, ON, Canada.
Mahmoud AbdelkarimBiomedical Engineering, Faculty of Engineering, University of Toronto, Toronto, ON, Canada.
David T CrambDepartment of Chemistry and Biology, Faculty of Science, Toronto Metropolitan University, Toronto, ON, Canada.
Sarah J ChildsDepartment of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Kristina D RinkerDepartment of Chemical and Petroleum Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada. kdrinker@ucalgary.ca.
Hagar I LaboutaBiomedical Engineering, Faculty of Engineering, University of Toronto, Toronto, ON, Canada. hagar.labouta@unityhealth.to.ORCID 0000-0001-7344-5893

Funding

New Frontiers Exploration NFRFE-2019-00210NSERC RGPIN-2019-07176NSERC RGPIN-2020-05679NSERC RTI NSERC RTI-2021-00374
6 · The paper itself

Abstract

Nanoparticles used for drug delivery often require intravenous administration exposing them to fluid forces within the vasculature, yet the impact of blood flow on nanoparticle delivery remains incompletely understood. Here, we utilized transgenic zebrafish embryos to investigate the relationship between the accumulation of fluorescently labeled PEGylated liposomes and various hemodynamic factors (such as flow velocity, wall shear stress (WSS), and flow pattern) across a wide range of angiogenic blood vessels. We reconstructed 3D models of vascular structures from confocal images and used computational fluid dynamics to calculate local WSS, velocities, and define flow patterns. The spatial distribution of fluorescently labeled liposomes was subsequently mapped within the same 3D space and correlated with local hemodynamic parameters. Through the integration of computational fluid dynamics and in vivo experimentation, we show that liposomes accumulated in vessel regions with WSS between 0.1-0.8 Pa, displaying an inverse linear correlation (R

Indexed as

LiposomesNeovascularization, PhysiologicStress, MechanicalZebrafishAnimalsAnimals, Genetically ModifiedBlood VesselsEmbryo, NonmammalianHemodynamicsHydrodynamicsPolyethylene GlycolsLiposomesPolyethylene GlycolsHemodynamic factorsNanoparticle vascular traffickingPassive targetingStealth liposomes

Identifiers

PMID39042244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.