Evidence map›Paper›PMID 39042242›Full record

ArticleJournal of hematopathology2024

Assessment for acceleration and transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma using histologic and immunohistochemical features: a case series.

Margaret E Moore, Nadine S Aguilera, Ifeyinwa Obiorah, Eli Williams, Elizabeth Courville

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Margaret E MooreDepartment of Pathology and Laboratory Medicine, University of Virginia, 1215 Lee Street, 3rdFloor Hospital Expansion, Charlottesville, VA, 22908, USA. mem4br@uvahealth.org.ORCID http://orcid.org/0000-0001-9149-5384
Nadine S AguileraDepartment of Pathology and Laboratory Medicine, University of Virginia, 1215 Lee Street, 3rdFloor Hospital Expansion, Charlottesville, VA, 22908, USA.
Ifeyinwa ObiorahDepartment of Pathology and Laboratory Medicine, University of Virginia, 1215 Lee Street, 3rdFloor Hospital Expansion, Charlottesville, VA, 22908, USA.
Eli WilliamsDepartment of Pathology and Laboratory Medicine, University of Virginia, 1215 Lee Street, 3rdFloor Hospital Expansion, Charlottesville, VA, 22908, USA.
Elizabeth CourvilleDepartment of Pathology and Laboratory Medicine, University of Virginia, 1215 Lee Street, 3rdFloor Hospital Expansion, Charlottesville, VA, 22908, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphologic features of aggressive/ "accelerated" chronic lymphocytic leukemia/small lymphocytic lymphoma (aCLL/SLL) have been described. Richter transformation (RT) also occurs in a subset of CLL/SLL cases. This case series examined inter-observer variability when assessing for aCLL/SLL and RT, with attention to how immunohistochemical (IHC) markers may assist in this evaluation. Twelve cases of CLL/SLL with available FFPE tissue were identified. H&E staining and IHC (CD3, CD20, CD5, CD23, LEF1, LAG3, C-MYC, PD-1, MUM1, Cyclin D1, BCL-6, p53, and Ki-67) were performed. Three hematopathologists reviewed each case. The pathologists provided a final interpretation of (1) CLL/SLL, (2) CLL/SLL with expanded and/or confluent proliferation centers or increased Ki-67 (aCLL/SLL), or (3) large cell transformation/DLBCL. The pathologists lacked consensus in the diagnosis in 6/12 cases (50%). The reviewers disagreed on the presence of expanded/confluent proliferation centers in 8/12 cases (67%). With the exception of Ki-67, no IHC marker showed a difference in the staining profile in aCLL/SLL or RT compared to low-grade cases. This series showed inter-observer variability in the evaluation for aCLL/SLL and RT. A study that serially examines genetic alterations in FFPE tissue and correlates the features with histology and IHC, at diagnosis and throughout the disease course, may help refine indicators of aggressive disease.

Indexed as

ImmunohistochemistryLeukemia, Lymphocytic, Chronic, B-CellAgedAged, 80 and overBiomarkers, TumorCell Transformation, NeoplasticFemaleHumansMaleMiddle AgedObserver VariationBiomarkers, TumorAggressive featuresChronic lymphocytic leukemiaImmunohistochemistrySmall lymphocytic lymphomaTransformation

Identifiers

PMID39042242
PMCPMC11324784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.