Evidence map›Paper›PMID 39042216›Full record

ArticleJournal of molecular histology2024

Ameliorative effect of pedunculoside on sepsis-induced acute lung injury, inflammation and pulmonary fibrosis in mice model via suppressing AKT/NF-κB pathway.

Xiangbo Li, Ruiming Xu, Kaiguo Zhou, Qiumei Cao

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Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiangbo LiEmergency Department, Beijing Tongren Hospital, Capital Medical University, No. 2, Xihuan South Road, Economic and Technological Development Zone, Daxing District, Beijing, 100176, China.
Ruiming XuEmergency Department, Beijing Tongren Hospital, Capital Medical University, No. 2, Xihuan South Road, Economic and Technological Development Zone, Daxing District, Beijing, 100176, China.
Kaiguo ZhouEmergency Department, Beijing Tongren Hospital, Capital Medical University, No. 2, Xihuan South Road, Economic and Technological Development Zone, Daxing District, Beijing, 100176, China.
Qiumei CaoEmergency Department, Beijing Tongren Hospital, Capital Medical University, No. 2, Xihuan South Road, Economic and Technological Development Zone, Daxing District, Beijing, 100176, China. caoqiumeidoc@21cn.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesSepsis-induced acute lung injury (ALI) is the typical complications of sepsis with a high global incidence and mortality. Inhibition of inflammatory response is a crucial and effective strategy for sepsis-induced ALI. Pedunculoside (PE) has been shown to have an anti-inflammatory effect on various diseases. However, the effect and mechanism of PE on sepsis-induced ALI remain unknown. MATERIALS/

methodsA mice model of sepsis-induced ALI was constructed by cecal ligation and puncture (CLP). The effect of PE on the CLP-induced mice were assessed using pathological staining, terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL), reverse transcription quantitative polymerase chain reaction (RT-qPCR), enzyme-linked immunosorbent assay (ELISA) and western blot assays.

resultsPE reduced pathological symptoms and scores, apoptosis and the W/D ratio of lung tissues in CLP-induced mice. Besides, PE decreased the level of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α), pulmonary fibrosis and the expression of fibrosis markers. Mechanically, PE inhibited AKT/NF-κB signaling in CLP-induced mice. Activation of AKT/NF-κB pathway abolished the ameliorative effect of PE on the pathological symptoms, the release of inflammatory factors and pulmonary fibrosis of CLP-induced mice.

conclusionPE improved inflammation and pulmonary fibrosis by inhibiting AKT/NF-κB pathway in CLP-induced mice.

Indexed as

Acute Lung InjuryDisease Models, AnimalInflammationNF-kappa BProto-Oncogene Proteins c-aktPulmonary FibrosisSepsisSignal TransductionAnimalsApoptosisCytokinesMaleMiceCytokinesNF-kappa BProto-Oncogene Proteins c-aktAcute lung injuryAKT/NF-κBFibrosisInflammationPedunculoside

Identifiers

PMID39042216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.