Evidence map›Paper›PMID 39042215›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2024

Nonsteroidal anti-inflammatory drugs for analgesia in intensive care units: a survey of Canadian critical care physicians.

Kimberly B Tworek, Chen-Hsiang Ma, Dawn Opgenorth, Nadia Baig, Fernando G Zampieri, John Basmaji, Bram Rochwerg, Kimberley Lewis, Sebastian Kilcommons, Sangeeta Mehta and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kimberly B TworekAlberta Health Services, Edmonton, AB, Canada. tworek@ualberta.ca.ORCID 0009-0003-7686-2993
Chen-Hsiang MaAlberta Health Services, Edmonton, AB, Canada.
Dawn OpgenorthAlberta Health Services, Edmonton, AB, Canada.
Nadia BaigAlberta Health Services, Edmonton, AB, Canada.
Fernando G ZampieriAlberta Health Services, Edmonton, AB, Canada.
John BasmajiDivision of Critical Care Medicine, Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Bram RochwergDepartment of Health Research Methods, Evidence & Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Kimberley LewisDepartment of Health Research Methods, Evidence & Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Sebastian KilcommonsFaculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Sangeeta MehtaSinai Health System, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Kimia HonarmandDivision of Critical Care, Department of Medicine, Mackenzie Health, Vaughan, ON, Canada.
H Tom StelfoxSinai Health System, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada.
M Elizabeth WilcoxInterdepartmental Division of Critical Care Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Demetrios J KutsogiannisAlberta Health Services, Edmonton, AB, Canada.
Kirsten M FiestAlberta Health Services, Edmonton, AB, Canada.
Constantine J KarvellasAlberta Health Services, Edmonton, AB, Canada.
Wendy SliglAlberta Health Services, Edmonton, AB, Canada.
Oleksa RewaAlberta Health Services, Edmonton, AB, Canada.
Janek SenaratneAlberta Health Services, Edmonton, AB, Canada.
Sameer SharifDivision of Critical Care Medicine, Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Sean M BagshawAlberta Health Services, Edmonton, AB, Canada.
Vincent I LauAlberta Health Services, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOpioids remain the mainstay of analgesia for critically ill patients, but its exposure is associated with negative effects including persistent use after discharge. Nonsteroidal anti-inflammatory drugs (NSAIDs) may be an effective alternative to opioids with fewer adverse effects. We aimed to describe beliefs and attitudes towards the use of NSAIDs in adult intensive care units (ICUs).

methodsOur survey of Canadian ICU physicians was conducted using a web-based platform and distributed through the Canadian Critical Care Society (CCCS) email distribution list. We used previously described survey development methodology including question generation and reduction, pretesting, and clinical sensibility and pilot testing.

resultsWe received 115 completed surveys from 321 CCCS members (36%). Nonsteroidal anti-inflammatory drugs use was most described as "rarely" (59 respondents, 51%) with the primary concern being adverse events (acute kidney injury [108 respondents, 94%] and gastrointestinal bleeding [92 respondents, 80%]). The primary preferred analgesic was acetaminophen (75 respondents, 65%) followed by opioids (40 respondents, 35%). Most respondents (91 respondents, 80%) would be willing to participate in a randomized controlled trial examining NSAID use in critical care.

conclusionsIn our survey, Canadian critical care physicians did not mention commonly using NSAIDs primarily because of concerns about adverse events. Nevertheless, respondents were interested in further studying ketorolac, a commonly used NSAID outside of the ICU, in critically ill patients.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalCritical CareIntensive Care UnitsAcetaminophenAdultAnalgesiaAnalgesics, OpioidAttitude of Health PersonnelCanadaCritical IllnessFemaleHumansMalePhysiciansPractice Patterns, Physicians'Surveys and QuestionnairesAcetaminophenAnalgesics, OpioidAnti-Inflammatory Agents, Non-Steroidalcritical careketorolacmorbiditymortalityNSAIDspain control

Identifiers

PMID39042215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.