Evidence map›Paper›PMID 39042207›Full record

ArticleVirchows Archiv : an international journal of pathology2024

The clinicopathological and prognostic significance of autonomic nerves in salivary duct carcinoma.

Manami Kajiwara, Hideaki Takahashi, Masato Nakaguro, Daisuke Kawakita, Hideaki Hirai, Yoshitaka Utsumi, Makoto Urano, Yukiko Sato, Kiyoaki Tsukahara, Satoshi Kano and 21 more

Abstract read
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Manami KajiwaraDepartment of Anatomic Pathology, Tokyo Medical University, Shinjuku-Ku, Tokyo, Japan.
Hideaki TakahashiDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Yokohama, Japan.
Masato NakaguroDepartment of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.ORCID http://orcid.org/0000-0001-6987-3043
Daisuke KawakitaDepartment of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.ORCID http://orcid.org/0000-0003-3794-2790
Hideaki HiraiDepartment of Anatomic Pathology, Tokyo Medical University, Shinjuku-Ku, Tokyo, Japan.
Yoshitaka UtsumiDepartment of Anatomic Pathology, Tokyo Medical University, Shinjuku-Ku, Tokyo, Japan.
Makoto UranoDepartment of Diagnostic Pathology, School of Medicine, Bantane Hospital, Fujita Health University, Nakagawa-Ku, Nagoya, Japan.
Yukiko SatoDivision of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto-Ku, Tokyo, Japan.
Kiyoaki TsukaharaDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Shinjuku-Ku, Tokyo, Japan.
Satoshi KanoDepartment of Otolaryngology - Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Kenji OkamiDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Tokai University, Isehara, Japan.
Hiroyuki OzawaDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan.
Keisuke YamazakiDepartment of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
Takuro OkadaDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Japan.
Akira ShimizuDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Shinjuku-Ku, Tokyo, Japan.
Kenji HanyuDepartment of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Shinjuku-Ku, Tokyo, Japan.
Akihiro SakaiDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Tokai University, Isehara, Japan.
Mayu YamauchiDepartment of Otolaryngology, Head and Neck Surgery, School of Medicine, Tokai University, Isehara, Japan.
Mariko SekimizuDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan.
Toyoyuki HanazawaDepartment of Otorhinolaryngology/Head & Neck Surgery, Chiba University Graduate School of Medicine, Chuo-Ku, Chiba, Japan.
Yuki SaitoDepartment of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Yushi UekiDepartment of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo-Ku, Niigata, Japan.
Yoshitaka HonmaDepartment of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, Chuo-Ku, Tokyo, Japan.
Tomoyuki AraiDepartment of Otorhinolaryngology/Head & Neck Surgery, Chiba University Graduate School of Medicine, Chuo-Ku, Chiba, Japan.
Sho IwakiDepartment of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Koji YamamuraDepartment of Otolaryngology - Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
Yorihisa ImanishiDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinjuku-Ku, Tokyo, Japan.
Yuichiro SatoDepartment of Head and Neck Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
Yuichiro TadaDepartment of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital, Minato-Ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0159-8660
Toshitaka NagaoDepartment of Anatomic Pathology, Tokyo Medical University, Shinjuku-Ku, Tokyo, Japan. nagao-t@tokyo-med.ac.jp.ORCID http://orcid.org/0000-0003-2075-9738
Multi-institutional Joint SDC Study Group in Japan

Funding

Japan Society for the Promotion of Science 21K09616Japan Society for the Promotion of Science 22K06939Japan Society for the Promotion of Science 22K06969Japan Society for the Promotion of Science 23K06432
6 · The paper itself

Abstract

Many researchers have focused on the role of the autonomic nervous system in the tumor microenvironment. Autonomic nerves include the sympathetic and parasympathetic nerves, which are known to induce cancer growth and metastasis. However, in salivary duct carcinoma (SDC), a rare and highly malignant tumor, the issue should be investigated from both biological and therapeutic perspectives. We explored the clinicopathological and prognostic implications of the autonomic nerves in 129 SDCs. Immunohistochemistry was performed to determine the nature of each nerve using antibodies against S100, tyrosine hydroxylase (TH) as a sympathetic marker, and vesicular acetylcholine transporter (VAChT) as a parasympathetic marker. The area of each marker-positive nerve was digitized and evaluated quantitatively. Double immunofluorescence for TH and VAChT was performed in selected cases. The expression of the secreted neurotrophins was also examined. S100-positive nerves were present in the cancer tissue in 94 of 129 cases (72.9%). Among them, TH-positive sympathetic nerves and/or VAChT-positive parasympathetic nerves were identified in 92 cases (97.9%), and 59 cases (62.8%) had TH/VAChT-co-expressing nerves. Double immunofluorescence revealed a mosaic pattern of sympathetic and parasympathetic fibers in co-expressing nerve bundles. The presence of autonomic nerves, regardless of their area, was significantly associated with aggressive histological features, advanced T/N classification, and a poor prognosis, with shorter disease-free and overall survival. There was an association between some tumor immune microenvironment-related markers and the autonomic nerve status, but not the latter and the secreted neurotrophin expression. This study suggests that autonomic nerves might play a role in the progression of SDC.

Indexed as

Salivary Gland NeoplasmsAdultAgedAged, 80 and overAutonomic Nervous SystemAutonomic PathwaysBiomarkers, TumorCarcinoma, DuctalFemaleHumansImmunohistochemistryMaleMiddle AgedPrognosisS100 ProteinsSalivary DuctsBiomarkers, TumorS100 ProteinsTyrosine 3-MonooxygenaseVesicular Acetylcholine Transport ProteinsAutonomic nerveCancer neuroscienceParasympathetic nerveSalivary duct carcinomaSympathetic nerveTumor microenvironment

Identifiers

PMID39042207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.