Evidence map›Paper›PMID 39042016›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

Enzymatic Modulation of the Pulmonary Glycocalyx Enhances Susceptibility to

Cengiz Goekeri, Kerstin A K Linke, Karen Hoffmann, Elena Lopez-Rodriguez, Vladimir Gluhovic, Anne Voß, Sandra Kunder, Andreas Zappe, Sara Timm, Alina Nettesheim and 7 more

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
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  8. Article
  9. Enzymatic Modulation of the Pulmonary Glycocalyx Enhances Susceptibility toAmerican journal of respiratory cell and molecular biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Cengiz GoekeriDepartment of Infectious Diseases, Respiratory Medicine and Critical Care.ORCID 0000-0002-1616-4005
Kerstin A K LinkeDepartment of Infectious Diseases, Respiratory Medicine and Critical Care.
Karen HoffmannDepartment of Infectious Diseases, Respiratory Medicine and Critical Care.
Elena Lopez-RodriguezInstitute of Functional Anatomy, and.
Vladimir GluhovicInstitute of Functional Anatomy, and.
Anne VoßInstitute of Veterinary Pathology and.
Sandra KunderInstitute of Veterinary Pathology and.
Andreas ZappeInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Sara TimmCore Facility Electron Microscopy, Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Alina NettesheimDepartment of Infectious Diseases, Respiratory Medicine and Critical Care.
Sebastian M K SchickingerDepartment of Infectious Diseases, Respiratory Medicine and Critical Care.
Christian M ZobelDepartment of Internal Medicine, Bundeswehrkrankenhaus Berlin, Berlin, Germany; and.
Kevin PagelInstitute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Achim D GruberInstitute of Veterinary Pathology and.ORCID 0000-0002-4502-0393
Matthias OchsInstitute of Functional Anatomy, and.
Martin WitzenrathDepartment of Infectious Diseases, Respiratory Medicine and Critical Care.
Geraldine NouaillesDepartment of Infectious Diseases, Respiratory Medicine and Critical Care.ORCID 0000-0003-1973-3119

Funding

Bundesministerium für Bildung und Forschung MAPVAP grant 16GW0247Charité 3R grantDeutsche Forschungsgemeinschaft C02Deutsche Forschungsgemeinschaft SFB 1340-372486779Jürgen Manchot Foundation StipendSanitätsakademie der Bundeswehr SoFo39K4
6 · The paper itself

Abstract

The pulmonary epithelial glycocalyx is rich in glycosaminoglycans such as hyaluronan and heparan sulfate. Despite their presence, the importance of these glycosaminoglycans in bacterial lung infections remains elusive. To address this, we intranasally inoculated mice with

Indexed as

GlycocalyxHeparan SulfateHyaluronic AcidHyaluronoglucosaminidaseLungStreptococcus pneumoniaeAnimalsDisease SusceptibilityHeparin LyaseHumansMiceMice, Inbred C57BLPneumococcal InfectionsPneumonia, PneumococcalHeparan SulfateHeparin LyaseHyaluronic AcidHyaluronoglucosaminidaseacute lung injurycommunity-acquired pneumoniaglycosaminoglycansheparan sulfatehyaluronan

Identifiers

PMID39042016
PMCPMC11622634

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.