Evidence map›Paper›PMID 39042015›Full record

ArticleEmerging microbes & infections2024

Biotech's role in advancing HIV vaccine development.

Roger Tatoud, Christian Brander, Carey Hwang, Jo Kennelly, Shan Lu, Kevin O'Neil, Jeffrey T Safrit, Iris Benhayoun, Julieta Firmat, Nelli Barriere

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roger TatoudOrigena Consulting, Ferney Voltaire, France.ORCID 0000-0002-3999-8264
Christian BranderAELIX Therapeutics, Catalonia, Spain.ORCID 0000-0002-0548-5778
Carey HwangVir Biotechnology, San Francisco, CA, USA.
Jo KennellyMalaika Vx, Toronto, Canada.
Shan LuWorcester HIV Vaccine, Worcester, MA, USA.ORCID 0000-0002-8417-7588
Kevin O'NeilUvax Bio, Newark, DE, USA.
Jeffrey T SafritImmunityBio, San Diego, CA, USA.
Iris BenhayounWorcester HIV Vaccine, Worcester, MA, USA.
Julieta FirmatInternational AIDS Society, Geneva Switzerland.ORCID 0009-0008-6261-7918
Nelli BarriereInternational AIDS Society, Geneva Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV vaccine development has been hindered by significant challenges over four decades. Despite persistent efforts, all efficacy trials to date have yielded disappointing results. This has pushed the field back to the discovery phase and created uncertainty about the future involvement of large pharmaceutical companies. Currently, the HIV vaccine landscape is dominated by startup biotech firms, which face a complex array of obstacles. These include evolving HIV prevention methods, waning interest in vaccine research, and difficulties securing sustainable funding. This viewpoint explores the challenges faced by these biotech companies and the support mechanisms necessary for their continued involvement in HIV vaccine development. By leveraging insights from both pharmaceutical and biotech sectors, we propose a multi-faceted approach that includes enhanced communication, fostering innovation, and implementing strategic funding models.

Indexed as

AIDS VaccinesBiotechnologyHIV InfectionsVaccine DevelopmentDrug DevelopmentDrug IndustryHumansAIDS VaccinesbiotechHIVHIV vaccinepharmaceutical industryresearch and development

Identifiers

PMID39042015
PMCPMC11321102

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.