Evidence map›Paper›PMID 39041864›Full record

Trial reportAnnals of the American Thoracic Society2024

Impact of Discontinuing Both Hypertonic Saline and Dornase Alfa after Elexacaftor-Tezacaftor-Ivacaftor in Cystic Fibrosis.

Nicole Mayer-Hamblett, Alex H Gifford, Margaret Kloster, Renee Russell, Andrew T Braun, Ronald L Gibson, Jordana E Hoppe, Raksha Jain, Rachel W Linnemann, Theodore G Liou and 6 more

Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Annals of the American Thoracic Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Elexacaftor/tezacaftor/ivacaftor is associated with long-term reduction in use of chronic respiratory therapies in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Observational
  4. Review
  5. Review
  6. Cystic Fibrosis Year in Review 2024.Pediatric pulmonology · 2025
    Review
  7. Article
  8. Observational
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Nicole Mayer-HamblettUniversity of Washington School of Medicine, Seattle, Washington.
Alex H GiffordUniversity Hospitals Cleveland Medical Center, Cleveland, Ohio.
Margaret KlosterSeattle Children's Hospital, Seattle, Washington.
Renee RussellSeattle Children's Hospital, Seattle, Washington.
Andrew T BraunUniversity of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.ORCID 0000-0003-4214-6350
Ronald L GibsonUniversity of Washington School of Medicine, Seattle, Washington.
Jordana E HoppeUniversity of Colorado School of Medicine, Aurora, Colorado.
Raksha JainUniversity of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-2407-7374
Rachel W LinnemannEmory University School of Medicine, Atlanta, Georgia.
Theodore G LiouUniversity of Utah School of Medicine, Salt Lake City, Utah.ORCID 0000-0003-0121-4847
Jerimiah LysingerBillings Clinic Pediatric Center, Billings, Montana.
Carlos MillaStanford University Medical Center, Palo Alto, California.
Kristin A RiekertJohns Hopkins University School of Medicine, Baltimore, Maryland.
Gregory S SawickiBoston Children's Hospital, Boston, Massachusetts.
Julia YoungSeattle Children's Hospital, Seattle, Washington.
David NicholsUniversity of Washington School of Medicine, Seattle, Washington.ORCID 0000-0001-8611-7960

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
Explanatory models of CF Survival, Infection and Intermediate Clinical OutcomesR01HL125520 · NHLBI · UNIVERSITY OF UTAH · PI LIOU, THEODORE GEH-LU · 2015 to 2018
$1.4M
Cystic Fibrosis Foundation 000527CC319Cystic Fibrosis Foundation 2P30DK089507NCATS NIH HHS UL1 TR002319NHLBI NIH HHS R01 HL125520NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AminophenolsBenzodioxolesCystic FibrosisDeoxyribonuclease IDrug CombinationsIndolesPyrazolesQuinolonesRecombinant ProteinsAdolescentAdultChildFemaleForced Expiratory VolumeHumansMaleAminophenolsBenzodioxolesDeoxyribonuclease Idornase alfaDrug Combinationselexacaftor, ivacaftor, tezacaftor drug combinationIndolesPyrazolesPyridinesPyrrolidinesQuinolinesQuinolonesRecombinant ProteinsSaline Solution, HypertonicCFTR modulatorstreatment burdentreatment discontinuation

Identifiers

PMID39041864
PMCPMC11568493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.