Evidence map›Paper›PMID 39041427›Full record

ArticleChemical research in toxicology2024

8-OxodGuo and Fapy•dG Mutagenicity in

Srijana Dasgupta, Shijun Gao, Haozhe Yang, Marc M Greenberg, Ashis K Basu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Srijana DasguptaDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.
Shijun GaoDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Haozhe YangDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Marc M GreenbergDepartment of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0002-5786-6118
Ashis K BasuDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0001-7951-4984

Funding

How Damaged DNA Forms, and its Subsequent Chemistry: Fundamental Studies and ApplicationsR35GM131736 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MARC M GREENBERG · 2019 to 2026
$4.3M
Biochemical studies on Fapy-dG with eukaryotic enzymes and in mammalian cellsR01ES027558 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GREENBERG, MARC M · 2017 to 2021
$1.7M
NIEHS NIH HHS R01 ES027558NIGMS NIH HHS R35 GM131736
6 · The paper itself

Abstract

Tandem lesions, which are defined by two or more contiguously damaged nucleotides, are a hallmark of ionizing radiation. Recently, tandem lesions containing 5-formyl-2'-deoxyuridine (5-fdU) flanked by a 5'-8-OxodGuo or Fapy•dG were discovered, and they are more mutagenic in human cells than the isolated lesions. In the current study, we examined replication of these tandem lesions in

Indexed as

8-Hydroxy-2'-DeoxyguanosineEscherichia coliDeoxyguanosineDeoxyuridineDNA DamageMutagenesisMutagensMutation8-Hydroxy-2'-DeoxyguanosineDeoxyguanosineDeoxyuridineMutagens

Identifiers

PMID39041427
PMCPMC11333159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.