ReviewEuropean journal of preventive cardiology2025
Early-onset atherosclerotic cardiovascular disease.
Review in European journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Are associations of childhood body mass index trajectories with early-onset coronary heart disease modified by parental history of cardiovascular disease?International journal of obesity (2005) · 2026Article
- Burden of atherosclerotic cardiovascular disease attributable to high body mass index, high fasting plasma glucose or high low density lipoprotein cholesterol in young and middle-aged adults from 1990 to 2050.Diabetology & metabolic syndrome · 2026Article
- Article
- The impact of the Elixhauser comorbidity index on length of stay in patients with coronary artery disease.BMC cardiovascular disorders · 2026Article
- Combination therapy with moderate-intensity statins and ezetimibe and risk of incident PCI/CABG in atherosclerotic cardiovascular disease: a propensity-matched cohort study.The Lancet regional health. Western Pacific · 2026Article
- Unveiling novel drug targets for atherosclerosis: A Mendelian randomization analysis.Medicine · 2026Article
- The diagnostic value and mechanistic role of miR-20b-5p in premature coronary artery disease.Irish journal of medical science · 2026Article
- Comparative prognostic value of TyG index and TyG-BMI for 90-day all-cause mortality in critically ill older adults with ASCVD: a machine learning analysis of the MIMIC-IV database.Cardiovascular diabetology · 2026Article
- Article
- Spatial inequalities in cardiovascular health: a cross-sectional study with small-area health insurance claims and individual-level primary care data in Belgium.BMC public health · 2026Article
- T‑cadherin and its impact on human diseases (Review).Molecular medicine reports · 2026Review
- A Novel A-Kinase-Anchoring Protein 9 Variant in Premature Coronary Artery Disease: A Case Series.Molecular genetics & genomic medicine · 2026Article
- The role of IL-6 in atherosclerosis: a narrative review.Frontiers in cardiovascular medicine · 2026Review
- China precision nutrition biobank: protocol of a prospective cohort study on diet, human phenotype/genotype, and early-onset chronic diseases.Nutrition journal · 2025Article
- Profiling endothelial function, oxidative stress and inflammatory biomarkers in individuals with various cardiovascular risk factors: the African-PREDICT study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The positive correlation between the triglyceride glucose-body mass index and the presence and severity of early-onset coronary artery disease.Annals of medicine · 2025Article
- Risk prediction of early-onset myocardial infarction using plasma proteomics, conventional risk factors, and polygenic risk score.Nutrition & metabolism · 2025Article
- Article
- Nanodelivery of Bioactive Natural Products: A Targeted Therapeutic Breakthrough for Atherosclerosis.Pharmaceutics · 2025Review
- The mitochondrial dysfunction, alongside the modifiable burden of traditional risk factors, drives the development of early-onset coronary artery disease.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
- Commented on by
Authors and funding
8 authors.
Funding
Abstract
Recent trends indicate a concerning increase in early-onset atherosclerotic cardiovascular disease (ASCVD) among younger individuals (men aged <55 years women aged <65 years). These findings highlight the pathobiology of ASCVD as a disease process that begins early in life and underscores the need for more tailored screening methods and preventive strategies. Increasing attention has been placed on the growing burden of traditional cardiometabolic risk factors in young individuals while also recognizing unique factors that mediate risk of pre-mature atherosclerosis in this demographic such as substance use, socioeconomic disparities, adverse pregnancy outcomes, and chronic inflammatory states that contribute to the increasing incidence of early ASCVD. Additionally, mounting evidence has pointed out significant disparities in the diagnosis and management of early ASCVD and cardiovascular outcomes based on sex and race. Moving towards a more personalized approach, emerging data and technological developments using diverse tools such as polygenic risk scores and coronary artery calcium scans have shown potential in earlier detection of ASCVD risk. Thus, we review current evidence on causal risk factors that drive the increase in early ASCVD and highlight emerging tools to improve ASCVD risk assessment in young individuals.
Indexed as
Identifiers
39041374What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.