Evidence map›Paper›PMID 39041271›Full record

SynthesisCurrent molecular medicine2025

The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review.

Maryam Nazarian, Pouria Mohammadparast-Tabas, Mohammad Sadra Harifi-Mood, Hamed Aramjoo, Ahmad Bavali-Gazik, Amirhossein Saberi, Yasaman Peyghambari, Peyman Mohammadparast-Tabas, Amirhosein Anghoshtary, Saeed Samarghandian and 1 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maryam NazarianStudent Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Pouria Mohammadparast-TabasStudent Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Mohammad Sadra Harifi-MoodClinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Hamed AramjooDepartment of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.
Ahmad Bavali-GazikStudent Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Amirhossein SaberiDepartment of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Yasaman PeyghambariStudent Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Peyman Mohammadparast-TabasStudent Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Amirhosein AnghoshtaryMedical Physics Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Saeed SamarghandianDepartment of Medical Physiology, School of Medicine, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Tahereh FarkhondehDepartment of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have indicated an association between cadmium (Cd) exposure and the induction of thyroid dysfunction in animal models. Objective and Aims: There are inconsistent findings on the effect of Cd on the thyroid gland. Therefore, this systematic study was designed to determine the association between changes in thyroid function markers and Cd exposure in animals Methods: The search was performed on Scopus, PubMed, Web of Science and databases, and Google Scholar until May 2023. Studies on the relationship between Cd exposure and fish's thyroid function were conducted on rodents and fish.

resultsIn total, 171 articles were obtained from the main databases using the search strategy mentioned in this study. Finally, 24 articles were selected according to our inclusion criteria for systematic studies. The findings indicated an increase/decrease or no change in triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) levels in rodents, fish, and animals exposed to Cd.

conclusionOur findings indicated an association between Cd exposure and thyroid dysfunction in rodents, fish, and other animals. However, the association between urinary and blood Cd levels and thyroid function remains unclear in humans because of controversial findings and a lack of strong mechanistic evidence. We perform large cohort human studies to the answer to this question.

Indexed as

CadmiumEnvironmental ExposureThyroid DiseasesThyroid GlandAnimalsFishesHumansThyroid Function TestsThyroid HormonesThyrotropinThyroxineTriiodothyronineCadmiumThyroid HormonesThyrotropinThyroxineTriiodothyronineCadmiumcadmium exposureT3T4thyroid functionthyroid glandTSH.

Identifiers

PMID39041271

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.