Evidence map›Paper›PMID 39040706›Full record

ArticleRSC advances2024

Synthesis of novel fatty acid 3,4-dihydropyrimidin-2-(1

E A M Rios, C M Dea, E R F B Dos Santos, M G M D'Oca, D S Rampon, F M Nachtigall, L S Santos, L Guzman, R Moore-Carrasco, D Rebolledo-Mira and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Synthesis andRSC advances · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

E A M RiosLaboratory of Polymers and Catalysis (LAPOCA), Department of Chemistry, Federal University of Paraná - UFPR P. O. Box 19061 Curitiba PR 81531-990 Brazil carolinedoca@ufpr.br.
C M DeaLaboratory of Polymers and Catalysis (LAPOCA), Department of Chemistry, Federal University of Paraná - UFPR P. O. Box 19061 Curitiba PR 81531-990 Brazil carolinedoca@ufpr.br.
E R F B Dos SantosLaboratory of Polymers and Catalysis (LAPOCA), Department of Chemistry, Federal University of Paraná - UFPR P. O. Box 19061 Curitiba PR 81531-990 Brazil carolinedoca@ufpr.br.
M G M D'OcaKolbe's Laboratory of Organic Synthesis, Department of Chemistry, Federal University of Paraná - UFPR P. O. Box 19032 Curitiba PR 81531-990 Brazil.
D S RamponLaboratory of Polymers and Catalysis (LAPOCA), Department of Chemistry, Federal University of Paraná - UFPR P. O. Box 19061 Curitiba PR 81531-990 Brazil carolinedoca@ufpr.br.ORCID https://orcid.org/0000-0003-0712-6645
F M NachtigallInstituto de Ciencias Aplicadas - Universidad Autónoma de Chile Talca 3467987 Chile.
L S SantosLaboratory of Asymmetric Synthesis, Chemistry Institute of Natural Resources, Universidad de Talca Talca 3460000 Chile.ORCID https://orcid.org/0000-0002-1697-4200
L GuzmanDepartamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca P.O. Box 747 Talca 3460000 Chile.
R Moore-CarrascoDepartamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca P.O. Box 747 Talca 3460000 Chile.
D Rebolledo-MiraCenter for Medical Research, School of Medicine, University of Talca Talca 3460000 Chile.
C R M D'OcaLaboratory of Polymers and Catalysis (LAPOCA), Department of Chemistry, Federal University of Paraná - UFPR P. O. Box 19061 Curitiba PR 81531-990 Brazil carolinedoca@ufpr.br.ORCID https://orcid.org/0000-0002-3932-1130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monastrol is the best-known small compound from the dihydropyrimidinones/thiones (DHPMs) heterocycle family, a cell-permeable molecule recognized as an inhibitor of mitotic kinesin Eg5, that is over-expressed in tumor cells and is a very promising target for the development of new drugs for cancer. The lipophilic properties of the DHPMs have been demonstrated to be of pivotal importance in the design of new molecules. This work describes the synthesis and antitumoral activity of novel C5-substituted fatty-DHPMs against breast and gastric cancer cell lines. The compounds were synthesized

Identifiers

PMID39040706
PMCPMC11261338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.