ArticleHeliyon2024
Deep learning for predicting circular retinal nerve fiber layer thickness from fundus photographs and diagnosing glaucoma.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Deriving OCT-Equivalent Retinal Nerve Fiber Layer Thickness Maps from Fundus Photographs with Deep Learning Improves Glaucoma Diagnosis.Ophthalmology science · 2026Article
- Genetic discovery using deep learning-derived optic nerve integrity phenotypes.medRxiv : the preprint server for health sciences · 2026Article
- Deep Learning-Based Generation of Retinal Nerve Fibre Layer Thickness Maps from Fundus Photographs: A Comparative Analysis of U-Net Architectures for Accessible Glaucoma Assessment.Life (Basel, Switzerland) · 2026Article
- Traditional Chinese Medicine Modernization in Diagnosis and Treatment: Utilizing Artificial Intelligence and Nanotechnology.MedComm · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to propose a new deep learning (DL) approach to automatically predict the retinal nerve fiber layer thickness (RNFLT) around optic disc regions in fundus photography trained by optical coherence tomography (OCT) and diagnose glaucoma based on the predicted comprehensive information about RNFLT. Methods: A total of 1403 pairs of fundus photographs and OCT RNFLT scans from 1403 eyes of 1196 participants were included. A residual deep neural network was trained to predict the RNFLT for each local image in a fundus photograph, and then a RNFLT report was generated based on the local images. Two indicators were designed based on the generated report. The support vector machines (SVM) algorithm was used to diagnose glaucoma based on the two indicators. Results: A strong correlation was found between the predicted and actual RNFLT values on local images. On three testing datasets, we found the Pearson Conclusions: We established a novel local image-based DL approach to provide comprehensive quantitative information on RNFLT in fundus photographs, which was used to diagnose glaucoma. In addition, training a deep neural network based on local images to predict objective detail information in fundus photographs provided a new paradigm for the diagnosis of ophthalmic diseases.
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Registered trials
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