Evidence map›Paper›PMID 39040342›Full record

ArticleHeliyon2024

Water soluble curcumin with alkyl sulfonate moiety: Synthesis, and anticancer efficacy.

Alaa Janem, Ghader Omar, Othman Hamed, Shehdeh Jodeh, Abdalhadi Deghles, Avni Berisha, Waseem Mansour, Saber Abu Jabal, Oswa Fares, Ataa Jaser and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alaa JanemChemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Ghader OmarBiology Department, Faculty of Sciences An-Najah National University, P.O. Box 7, Nablus, Palestine.
Othman HamedChemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Shehdeh JodehChemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Abdalhadi DeghlesDepartment of Chemistry, Istiqlala University, Jericho, Palestine.
Avni BerishaDepartment of Chemistry, Faculty of Natural and Mathematics Science, University of Prishtina, Prishtina, 10000, Republic of Kosovo.
Waseem MansourChemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Saber Abu JabalChemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Oswa FaresChemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Ataa JaserChemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Ameed AmirehChemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Ghaleb AdwanBiology Department, Faculty of Sciences An-Najah National University, P.O. Box 7, Nablus, Palestine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumin is classified as a chemotherapeutic medication because of its potential against numerous cancer cell lines and ability to inhibit cancer cell proliferation. Despite these findings, curcumin has yet to be commercialized as a drug due to its low water solubility, low absorption, and restricted bioavailability. As a result, there is a demand for water-soluble curcumin with improved solubility, bioavailability, and thus bioactivity. In this study we report the synthesis and the anticancer activities of water-soluble curcumins derivatives with alkyl sulfonate moiety. The target water-soluble curcumin with alkyl sulfonate moieties was created utilizing a straightforward technique that involved reacting curcumin with various sultones. The cytotoxic (24 h) and cytostatic (72 h) anticancer effect on breast carcinoma (MCF-7), liver carcinoma (HepG2), skin melanoma (B16-F110), colon human cancer and HeLa cervical carcinoma cell lines viability % via MTT assay were determined for the prepared derivatives. Results showed that curcumin-derived compounds have a pronounced cytostatic anticancer effect rather than cytotoxic one in relation to the compound type, cancer cell line type, and examined concentration compared to curcumin. The curcumin sulfonates outperformed curcumin activity against the tested cancer cells and showed to be powerful anticancer candidate drugs as supported by the theoretical calculations. This is evident by their high capacity to form H-bonding during docking with the amino acid side chains and the Vina docking score.

Indexed as

AnticancerCurcuminHela cellsMolecular dockingSultone

Identifiers

PMID39040342
PMCPMC11261864

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.