Evidence map›Paper›PMID 39040197›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Long COVID Brain Fog Treatment: Findings from a Pilot Randomized Controlled Trial of Constraint-Induced Cognitive Therapy.

Gitendra Uswatte, Edward Taub, Karlene Ball, Brandon S Mitchell, Jason A Blake, Staci McKay, Fedora Biney, Olesya Iosipchuk, Piper Hempfling, Elise Harris and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Gitendra UswatteDepartment of Psychology, University of Alabama at Birmingham.ORCID 0000-0003-4507-7098
Edward TaubDepartment of Psychology, University of Alabama at Birmingham.
Karlene BallDepartment of Psychology, University of Alabama at Birmingham.
Brandon S MitchellDepartment of Psychology, University of Alabama at Birmingham.
Jason A BlakeDepartment of Psychology, University of Alabama at Birmingham.ORCID 0000-0002-4575-2420
Staci McKayDepartment of Psychology, University of Alabama at Birmingham.
Fedora BineyDepartment of Physical Medicine and Rehabilitation, University of Alabama at Birmingham.
Olesya IosipchukDepartment of Psychology, University of Alabama at Birmingham.
Piper HempflingDepartment of Psychology, University of Alabama at Birmingham.
Elise HarrisDepartment of Psychology, University of Alabama at Birmingham.
Anne DickersonDepartment of Psychology, University of Alabama at Birmingham.
Kristine LokkenDepartment of Biostatistics, University of Alabama at Birmingham.
Amy J KnightDepartment of Neurology, University of Alabama at Birmingham.
Victor W MarkDepartment of Psychology, University of Alabama at Birmingham.
Shruti AgnihotriDepartment of Neurology, University of Alabama at Birmingham.
Gary CutterDepartment of Occupational Therapy, East Carolina University.

Funding

Transferring Speed of Processing Gains to Everyday Cognitive Tasks after StrokeR01AG070049 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BALL, KARLENE K, USWATTE, GITENDRA · 2021 to 2024
$2.6M
NIA NIH HHS R01 AG070049
6 · The paper itself

Abstract

Purpose: Long COVID brain fog is often disabling. Yet, no empirically-supported treatments exist. This study's objectives were to evaluate feasibility and efficacy, provisionally, of a new rehabilitation approach, Constraint-Induced Cognitive Therapy (CICT), for post-COVID-19 cognitive sequelae. Design: Sixteen community-residents ≥ 3-months post-COVID-19 infection with mild cognitive impairment and dysfunction in instrumental activities of daily living (IADL) were enrolled. Participants were randomized to Immediate-CICT or treatment-as-usual (TAU) with crossover to CICT. CICT combined behavior change techniques modified from Constraint-Induced Movement Therapy with Speed of Processing Training, a computerized cognitive-training program. CICT was deemed feasible if (a) ≥80% of participants completed treatment, (b) the same found treatment highly satisfying and at most moderately difficult, and (c) <2 study-related, serious adverse-events occurred. The primary outcome was IADL performance in daily life (Canadian Occupational Performance Measure). Employment status and brain fog (Mental Clutter Scale) were also assessed. Results: Fourteen completed Immediate-CICT ( Conclusions: CICT has promise for reducing brain fog, improving IADL, and promoting returning-to-work in adults with Long COVID. Findings warrant a large-scale RCT with an active-comparison group.

Indexed as

cognitive rehabilitationemploymentlong COVID brain fogPost-acute COVID-19 Syndromeprocessing speed

Identifiers

PMID39040197
PMCPMC11261935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.