Evidence map›Paper›PMID 39040072›Full record

ArticleiScience2024

Investigation of a fluorescent reporter microenvironment niche labeling strategy in experimental brain metastasis.

Matteo Massara, Bastien Dolfi, Vladimir Wischnewski, Emma Nolan, Werner Held, Ilaria Malanchi, Johanna A Joyce

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matteo MassaraDepartment of Oncology, University of Lausanne, 1011 Lausanne, Switzerland.
Bastien DolfiDepartment of Oncology, University of Lausanne, 1011 Lausanne, Switzerland.
Vladimir WischnewskiDepartment of Oncology, University of Lausanne, 1011 Lausanne, Switzerland.
Emma NolanTumour-Host Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Werner HeldDepartment of Oncology, University of Lausanne, 1011 Lausanne, Switzerland.
Ilaria MalanchiTumour-Host Interaction Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Johanna A JoyceDepartment of Oncology, University of Lausanne, 1011 Lausanne, Switzerland.

Funding

Wellcome Trust FC001112
6 · The paper itself

Abstract

Brain metastases are the most common brain tumors in patients and are associated with poor prognosis. Investigating the colonization and outgrowth of brain metastases is challenging given the complexity of the organ, tissue sampling difficulty, and limited experimental models. To address this challenge, we employed a strategy to analyze the metastatic niche in established lesions, based on the release of a cell-penetrating mCherry tag from labeled tumor cells to neighboring niche cells, using different brain metastasis mouse models. We found that CD206+ macrophages were the most abundant cells taking up the mCherry label in established metastases.

Indexed as

CancerCell biologyMicroenvironment

Identifiers

PMID39040072
PMCPMC11261144

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.