Evidence map›Paper›PMID 39039558›Full record

ArticleTrials2024

Update: Vitamin D

Nyasha Veronica Dzavakwa, Molly Chisenga, Grace McHugh, Suzanne Filteau, Celia Louise Gregson, Lackson Kasonka, Katharina Kranzer, Hildah Banda Mabuda, Hilda Mujuru, Nicol Redzo and 5 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nyasha Veronica DzavakwaBiomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe. nyasha.dzavakwa@lshtm.ac.uk.ORCID http://orcid.org/0000-0003-3547-8146
Molly ChisengaUniversity Teaching Hospital, Lusaka, Zambia.
Grace McHughBiomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe.
Suzanne FilteauLondon School of Hygiene & Tropical Medicine, London, UK.
Celia Louise GregsonMusculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, UK.
Lackson KasonkaUniversity Teaching Hospital, Lusaka, Zambia.
Katharina KranzerBiomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe.
Hildah Banda MabudaUniversity Teaching Hospital, Lusaka, Zambia.
Hilda MujuruDepartment of Paediatrics, University of Zimbabwe, Harare, Zimbabwe.
Nicol RedzoBiomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe.
Sarah Rowland-JonesNuffield Department of Medicine, University of Oxford, Oxford, UK.
Ulrich E SchaibleResearch Centre Borstel, Leibniz Lung Centre, Borstel, Germany.
Victoria SimmsBiomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe.
Rashida Abbas FerrandBiomedical Research and Training Institute, 10 Seagrave Road, Harare, Zimbabwe.
VITALITY team

Funding

European and Developing Countries Clinical Trials Partnership RIA2018CO-2512
6 · The paper itself

Abstract

backgroundOf the 2 million children living with HIV globally, 90% live in sub-Saharan Africa. Despite antiretroviral therapy, longstanding HIV infection is associated with several chronic complications in children including growth failure, particularly stunting and delayed puberty. Vitamin D deficiency, which is highly prevalent among children living with HIV in sub-Saharan Africa, has further adverse impact on bone health. This trial aims to establish whether supplementation with vitamin D METHODS/

designWe will conduct an individually randomised, double-blinded, placebo-controlled trial of weekly high-dose vitamin D DISCUSSION: This is the largest trial to date of vitamin D supplementation in children living with HIV. Intervening to address deficits in bone accrual through childhood is critical for optimising adolescent and early adult bone health, and prevention of later adult osteoporotic fractures. Trial results will draw attention to the need to screen for and treat long-term comorbidities in children living with HIV in resource-limited settings.

trial registrationPan African Clinical Trials Registry PACTR20200989766029. Registered on September 3, 2020. URL of trial registry record: https://pactr.samrc.ac.za TRIAL STATUS: Participant follow-up completed; data analysis ongoing.

Indexed as

Bone DensityCalcium CarbonateCholecalciferolDietary SupplementsHIV InfectionsRandomized Controlled Trials as TopicAdolescentAge FactorsChildDouble-Blind MethodFemaleHumansMaleTime FactorsTreatment OutcomeVitamin D DeficiencyCalcium CarbonateCholecalciferolAdolescentsBone densityCalcium carbonateGut microbiomeHIVImmune functionPubertal delayStuntingVitamin D3

Identifiers

PMID39039558
PMCPMC11264400

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.