ArticlePediatric research2024
Prognostic value of quantitative EEG in early hours of life for neonatal encephalopathy and neurodevelopmental outcomes.
Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Association of fetal inflammatory response with brain MRI findings and neurodevelopmental outcomes in preterm infants.Pediatric research · 2026Article
- Mitochondrial dysfunction in neonatal brain injury: from molecular mechanisms to therapeutic interventions.Journal of translational medicine · 2026Review
- Early outcome-prediction with an automated EEG background trend in hypothermia-treated newborns with encephalopathy.Pediatric research · 2026Article
- A Pilot Study on Dynamic Multimodal Neuromonitoring for Predicting Neurodevelopmental Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy.Developmental neuroscience · 2026Article
- Different Patterns of Cortical Electrical Activity by Tactile, Acoustic and Visual Stimuli in Infants: An EEG Exploratory Study.Diagnostics (Basel, Switzerland) · 2025Article
- Automated EEG Background Analysis and 2-Year Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy.JAMA network open · 2025Article
- Extending the Branches of Neonatal Neurocritical Care.Seminars in perinatology · 2025Review
- Multi-organ dysfunction across the neonatal encephalopathy spectrum.Pediatric research · 2025Article
- Autonomous screening of infants at high risk for neurodevelopmental impairments using a radar sensor and machine learning.Scientific reports · 2025Article
- Development of spontaneous and sensory evoked network activity in rodent cerebral cortexFrontiers in cellular neuroscience · 2025Review
- Automated assessment of EEG background for neurodevelopmental prediction in neonatal encephalopathy.Annals of clinical and translational neurology · 2024Article
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Abstract
backgroundThe ability to determine severity of encephalopathy is crucial for early neuroprotective therapies and for predicting neurodevelopmental outcome. The objective of this study was to assess a novel brain state of newborn (BSN) trend to distinguish newborns with presence of hypoxic ischemic encephalopathy (HIE) within hours after birth and predict neurodevelopmental outcomes at 2 years of age.
methodThis is a prospective cohort study of newborns at 36 weeks' gestation or later with and without HIE at birth. The Total Sanart Score (TSS) was calculated based on a modified Sarnat exam within 6 h of life. BSN was calculated from electroencephalogram (EEG) measurements initiated after birth. The primary outcome at 2 year of age was a diagnosis of death or disability using the Bayley Scales of Infant Development III.
resultsBSN differentiated between normal and abnormal neurodevelopmental outcomes throughout the entire recording period from 6 h of life. Additionally, infants with lower BSN values had higher odds of neurodevelopmental impairment and HIE. BSN distinguished between normal (n = 86) and HIE (n = 46) and showed a significant correlation with the concomitant TSS.
conclusionBSN is a sensitive real-time marker for monitoring dynamic progression of encephalopathy and predicting neurodevelopmental impairment. IMPACT: This is a prospective cohort study to investigate the ability of brain state of newborn (BSN) trend to predict neurodevelopmental outcome within the first day of life and identify severity of encephalopathy. BSN predicts neurodevelopmental outcomes at 2 years of age and the severity of encephalopathy severity. It also correlates with the Total Sarnat Score from the modified Sarnat exam. BSN could serve as a promising bedside trend aiding in accurate assessment and identification of newborns who may benefit from additional neuroprotection therapies.
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