Evidence map›Paper›PMID 39039292›Full record

ArticleSurgical endoscopy2024

Impact of primary endoscopic resection on oncological outcomes after esophagectomy for cancer: a retrospective propensity score-based cohort study.

Hugo Teixeira-Farinha, Hélène Béhal, Emeline Cailliau, Arnaud Pasquer, Alain Duhamel, Jérémie Théréaux, Mael Chalret du Rieu, Jérémie H Lefevre, Kathleen Turner, Styliani Mantziari and 4 more

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01927016 (Factors Linked to Outcomes After Esophageal Cancer Surgery), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01927016 completednot on this map

Factors Linked to Outcomes After Esophageal Cancer Surgery: a Multicenter National Study

TypeobservationalSponsorUniversity Hospital, LilleRan2012 to 2013Enrolled2,944ConditionsEsophageal Neoplasm, Esophageal DiseaseArmsEsophagectomy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hugo Teixeira-FarinhaOeso-Gastric Surgery Unit, Department of Digestive Surgery, Magellan Center, Bordeaux University Hospital, Bordeaux, France.
Hélène BéhalBiostatistics Department, CHU Lille, 59000, Lille, France.
Emeline CailliauBiostatistics Department, CHU Lille, 59000, Lille, France.
Arnaud PasquerDigestive Surgery Department, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.
Alain DuhamelBiostatistics Department, CHU Lille, 59000, Lille, France.
Jérémie ThéréauxDepartment of General, Digestive and Metabolic Surgery, La Cavale Blanche University Hospital, Brest, France.
Mael Chalret du RieuService de Chirurgie Bariatrique, Ramsay Générale de Santé, Clinique Des Cedres, Cornebarrieu, France.
Jérémie H LefevreDepartment of Digestive and General Surgery, Hôpital Saint-Antoine, Sorbonne Université, Paris, France.
Kathleen TurnerDepartment of Gastrointestinal and Hepatic Surgery, Rennes University Hospital Center, Rennes, France.
Styliani MantziariDepartment of Visceral Surgery, CHUV, University Hospital of Lausanne, Lausanne, Switzerland.
Denis ColletOeso-Gastric Surgery Unit, Department of Digestive Surgery, Magellan Center, Bordeaux University Hospital, Bordeaux, France.
Guillaume PiessenDepartment of Digestive and Oncological Surgery, Claude Huriez Hospital, CHU Lille, Lille, France.
Caroline GronnierOeso-Gastric Surgery Unit, Department of Digestive Surgery, Magellan Center, Bordeaux University Hospital, Bordeaux, France. caroline.gronnier@chu-bordeaux.fr.
FREGAT Network-AFC Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophageal cancer posed significant global health challenges, particularly due to poor survival rates, especially in advanced stages. Primary endoscopic resection had emerged as an alternative treatment for early esophageal cancer, aiming to preserve organ function and reduce surgical morbidity.

methodsThis retrospective multicenter cohort study included 334 patients with early esophageal cancer (T1a-b, N0) from 30 French-speaking European centers between 2000 and 2010. Patients underwent either primary endoscopic resection followed by esophagectomy (E group, n = 36) or esophagectomy alone (S group, n = 298). Cox proportional hazards models adjusted for TNM stage and propensity score weighting were used to assess the impact of primary endoscopic resection on recurrence-free survival (RFS), overall survival (OS), and postoperative complications.

resultsPrimary endoscopic resection did not significantly influence RFS (adjusted HR 0.92, 95% CI 0.31 to 2.68, p = 0.88) or OS (adjusted HR 1.06, 95% CI 0.35 to 3.13, p = 0.92) compared to esophagectomy alone. Initial higher thromboembolic complications in the endoscopic resection group were not significant after adjustment (adjusted OR 4.73, 95% CI 0.34 to 64.27, p = 0.24).

conclusionsPrimary endoscopic resection followed by esophagectomy for early esophageal cancer did not alter oncological outcomes or overall survival in this retrospective cohort. These findings supported the role of primary endoscopic resection as a safe initial treatment strategy, warranting validation in larger prospective studies. REGISTRATION: Our study was registered retrospectively on the Clinicaltrials.com website under the identifier NCT01927016. We acknowledge the importance of prospective registration and regret that this was not done before the commencement of the study.

Indexed as

Esophageal NeoplasmsEsophagectomyPropensity ScoreAgedEsophagoscopyFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment OutcomeEndoscopic resectionEsophageal cancerEsophagectomyOncological outcomes

Identifiers

PMID39039292

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.