Evidence map›Paper›PMID 39039278›Full record

ArticleNature genetics2024

Condensin I folds the Caenorhabditis elegans genome.

Moushumi Das, Jennifer I Semple, Anja Haemmerli, Valeriia Volodkina, Janik Scotton, Todor Gitchev, Ahrmad Annan, Julie Campos, Cyril Statzer, Alexander Dakhovnik and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. WormTagDB: A Systematic Survey of Endogenously Tagged Proteins inbioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Moushumi DasCell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, Bern, Switzerland.
Jennifer I SempleCell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, Bern, Switzerland.
Anja HaemmerliCell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, Bern, Switzerland.
Valeriia VolodkinaCell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, Bern, Switzerland.
Janik ScottonCell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, Bern, Switzerland.
Todor GitchevCell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-7470-0646
Ahrmad AnnanCell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0009-0000-5148-8219
Julie CamposCell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, Bern, Switzerland.
Cyril StatzerEidgenössische Technische Hochschule Zürich, Department of Health Sciences and Technology, Institute of Translational Medicine, Schwerzenbach, Switzerland.ORCID http://orcid.org/0000-0002-3980-8360
Alexander DakhovnikEidgenössische Technische Hochschule Zürich, Department of Health Sciences and Technology, Institute of Translational Medicine, Schwerzenbach, Switzerland.
Collin Y EwaldEidgenössische Technische Hochschule Zürich, Department of Health Sciences and Technology, Institute of Translational Medicine, Schwerzenbach, Switzerland.
Julien MozziconacciLaboratoire Structure et Instabilité des Génomes UMR 7196, Muséum National d'Histoire Naturelle, Paris, France.
Peter MeisterCell Fate and Nuclear Organization, Institute of Cell Biology, University of Bern, Bern, Switzerland. peter.meister@unibe.ch.ORCID http://orcid.org/0000-0002-6230-4216

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 31003A_176226/PP00P3_159320
6 · The paper itself

Abstract

The structural maintenance of chromosome (SMC) complexes-cohesin and condensins-are crucial for chromosome separation and compaction during cell division. During the interphase, mammalian cohesins additionally fold the genome into loops and domains. Here we show that, in Caenorhabditis elegans, a species with holocentric chromosomes, condensin I is the primary, long-range loop extruder. The loss of condensin I and its X-specific variant, condensin I

Indexed as

Adenosine TriphosphatasesCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsMultiprotein ComplexesX ChromosomeAnimalsCell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosomesCohesinsGenes, X-LinkedGenome, HelminthInterphaseAdenosine TriphosphatasesCaenorhabditis elegans ProteinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinscondensin complexesDNA-Binding ProteinsMultiprotein Complexes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.