Evidence map›Paper›PMID 39039227›Full record

ArticleScientific reports2024

Using a static magnetic field to attenuate the severity in COVID-19-invaded lungs.

Hsuan-Yu Lai, Kuo-Cheng Fan, Yen-Hua Lee, Wei-Zhen Lew, Wei-Yi Lai, Sheng-Yang Lee, Wei-Jen Chang, Haw-Ming Huang

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hsuan-Yu Lai *School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Kuo-Cheng Fan *Department of Dentistry, Taipei Medical University Wan Fang Hospital, 11696, Taipei, Taiwan.
Yen-Hua LeeDepartment of Animal Science, National Pingtung University of Science and Technology, 912301, Pingtung, Taiwan.
Wei-Zhen LewSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Wei-Yi LaiDepartment of Medical Research, Taipei Veterans General Hospital, 112062, Taipei, Taiwan.
Sheng-Yang LeeSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Wei-Jen ChangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Haw-Ming HuangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan. hhm@tmu.edu.tw.

Funding

College of Oral Medicine, Taipei Medical University TMUCOM-202306
6 · The paper itself

Abstract

Two important factors affecting the progress of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the S-protein binding function of ACE2 receptors and the membrane fluidity of host cells. This study aimed to evaluate the effect of static magnetic field (SMF) on S-protein/ACE2 binding and cellular membrane fluidity of lung cells, and was performed in vitro using a Calu-3 cell model and in vivo using an animal model. The ability of ACE2 receptors to bind to SARS-CoV-2 spike protein on host cell surfaces under SMF stimulation was evaluated using fluorescence images. Host lung cell membrane fluidity was tested using fluorescence polarization to determine the effects of SMF. Our results indicate that 0.4 T SMF can affect binding between S-protein and ACE2 receptors and increase Calu-3 cell membrane fluidity, and that SMF exposure attenuates LPS-induced alveolar wall thickening in mice. These results may be of value for developing future non-contact, non-invasive, and low side-effect treatments to reduce disease severity in COVID-19-invaded lungs.

Indexed as

Angiotensin-Converting Enzyme 2COVID-19LungMembrane FluiditySARS-CoV-2Spike Glycoprotein, CoronavirusAnimalsCell LineDisease Models, AnimalHumansMagnetic FieldsMiceProtein BindingACE2 protein, humanAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID39039227
PMCPMC11263632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.