ReviewGene therapy2025
Gene drives: an alternative approach to malaria control?
Review in Gene therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- The nanosd integral gene drive enables population modification of the malaria vector Anopheles gambiae.G3 (Bethesda, Md.) · 2026Article
- Local implementation of scalable malaria molecular surveillance in a low-resource setting: a North-South collaborative model.Malaria journal · 2026Article
- Article
- Knowledge, perspectives, and risk perceptions on gene drive and genetically modified mosquitoes for malaria control among African stakeholders: a scoping review protocol.Systematic reviews · 2026Article
- SkitoSnack 2.0 - A Bloodmeal Alternative for Anopheles and Aedes Mosquitoes.PLoS neglected tropical diseases · 2026Article
- Article
- Exploratory conversations with biodiversity-oriented civil society groups on the potential applications of gene drive-modified mosquitoes for malaria control in Tanzania.Transgenic research · 2026Article
- Values and ethics for implementation fidelity and integrity of public health policy in a multipolar world with conflicting value systems.Journal of public health (Oxford, England) · 2025Article
- Ivermectin's role in malaria control: the simplicity and the complexity.New microbes and new infections · 2025Article
- Babesiosis and Malaria in the United States: Epidemiology, Research Funding, Medical Progress, & Recommendations for Improvement.Epidemiologia (Basel, Switzerland) · 2025Article
- CRISPR/Cas9-germline editing ofScience advances · 2025Article
- Generalist Malaria Parasites and Host Imprinting: Unveiling Transcriptional Memory.Molecular biology and evolution · 2025Article
- The Journey of the Bacterial Symbiont Through the Olive Fruit Fly: Lessons Learned and Open Questions.Insects · 2025Review
- Routine malaria vaccination in Africa: a step toward malaria eradication?Malaria journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic modification for the control of mosquitoes is frequently touted as a solution for a variety of vector-borne diseases. There has been some success using non-insecticidal methods like sterile or incompatible insect techniques to control arbovirus diseases. However, control by genetic modifications to reduce mosquito populations or create mosquitoes that are refractory to infection with pathogens are less developed. The advent of CRISPR-Cas9-mediated gene drives may advance this mechanism of control. In this review, use and progress of gene drives for vector control, particularly for malaria, is discussed. A brief history of population suppression and replacement gene drives in mosquitoes, rapid advancement of the field over the last decade and how genetic modification fits into the current scope of vector control are described. Mechanisms of alternative vector control by genetic modification to modulate mosquitoes' immune responses and anti-parasite effector molecules as part of a combinational strategy to combat malaria are considered. Finally, the limitations and ethics of using gene drives for mosquito control are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.