Evidence map›Paper›PMID 39039140›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024

Neuroimaging for precision medicine in psychiatry.

Leanne M Williams, Susan Whitfield Gabrieli

Erratum issuedAbstract readReview
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
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  10. The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Leanne M Williams *Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA. leawilliams@stanford.edu.ORCID 0000-0001-9987-7360
Susan Whitfield Gabrieli *Department of Psychology, Northeastern University, 805 Columbus Ave, Boston, MA, 02120, USA.

Funding

Mapping connectomes for disordered emotional statesU01MH109985 · NIMH · STANFORD UNIVERSITY · PI WILLIAMS, LEANNE · 2017 to 2020
$3.1M
Neural Dimensions of Threat Reactivity and Regulation for Understanding AnxietyR01MH101496 · NIMH · STANFORD UNIVERSITY · PI WILLIAMS, LEANNE · 2013 to 2016
$2.3M
NIMH NIH HHS R01 MH101496NIMH NIH HHS U01 MH109985U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH101496U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH109985
6 · The paper itself

Abstract

Although the lifetime burden due to mental disorders is increasing, we lack tools for more precise diagnosing and treating prevalent and disabling disorders such as major depressive disorder. We lack strategies for selecting among available treatments or expediting access to new treatment options. This critical review concentrates on functional neuroimaging as a modality of measurement for precision psychiatry, focusing on major depressive and anxiety disorders. We begin by outlining evidence for the use of functional neuroimaging to stratify the heterogeneity of these disorders, based on underlying circuit dysfunction. We then review the current landscape of how functional neuroimaging-derived circuit predictors can predict treatment outcomes and clinical trajectories in depression and anxiety. Future directions for advancing clinically appliable neuroimaging measures are considered. We conclude by considering the opportunities and challenges of translating neuroimaging measures into practice. As an illustration, we highlight one approach for quantifying brain circuit function at an individual level, which could serve as a model for clinical translation.

Indexed as

Precision MedicineAnxiety DisordersBrainFunctional NeuroimagingHumansMajor Depressive DisorderNeuroimagingPsychiatry

Identifiers

PMID39039140
PMCPMC11525658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.