Evidence map›Paper›PMID 39039073›Full record

ArticleNature communications2024

The structural basis of the activation and inhibition of DSR2 NADase by phage proteins.

Ruiwen Wang, Qi Xu, Zhuoxi Wu, Jialu Li, Hao Guo, Tianzhui Liao, Yuan Shi, Ling Yuan, Haishan Gao, Rong Yang and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ruiwen Wang *MOE Key Laboratory of Rare Pediatric Diseases, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Qi Xu *Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.ORCID 0000-0002-9480-4776
Zhuoxi WuMOE Key Laboratory of Rare Pediatric Diseases, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Jialu LiZhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Hao GuoMOE Key Laboratory of Rare Pediatric Diseases, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Tianzhui LiaoMOE Key Laboratory of Rare Pediatric Diseases, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Yuan ShiZhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Ling YuanMOE Key Laboratory of Rare Pediatric Diseases, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Haishan GaoZhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.ORCID 0000-0002-4954-8793
Rong YangState Key Laboratory of Developmental Biology of Freshwater Fish, Engineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education Ministry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China. rongyang@hunnu.edu.cn.ORCID 0009-0000-8066-2386
Zhubing ShiZhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. shizhubing@westlake.edu.cn.ORCID 0000-0002-9624-4960
Faxiang LiMOE Key Laboratory of Rare Pediatric Diseases, Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China. chinalfx@163.com.ORCID 0000-0002-6442-9063

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32370742National Natural Science Foundation of China (National Science Foundation of China) 81901168Natural Science Foundation of Hunan Province (Hunan Provincial Natural Science Foundation) 2021JJ20075Natural Science Foundation of Hunan Province (Hunan Provincial Natural Science Foundation) 2022JJ20056Natural Science Foundation of Hunan Province (Hunan Provincial Natural Science Foundation) 2023JJ40437Science and Technology Bureau, Changsha (Changsha Municipal Science and Technology Bureau) kq2202088
6 · The paper itself

Abstract

DSR2, a Sir2 domain-containing protein, protects bacteria from phage infection by hydrolyzing NAD

Indexed as

Cryoelectron MicroscopyNADBacterial ProteinsBacteriophagesModels, MolecularNAD+ NucleosidaseProtein BindingProtein DomainsViral ProteinsViral Tail ProteinsBacterial ProteinsNADNAD+ NucleosidaseViral ProteinsViral Tail Proteins

Identifiers

PMID39039073
PMCPMC11263360

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.