ArticleCell death & disease2024
mtDNA release promotes cGAS-STING activation and accelerated aging of postmitotic muscle cells.
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Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
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Who cites it
40 citing papers in PubMed.
- Mechanistic reprogramming of the mtDNA-cGAS-STING axis in cellular senescence: from mitochondrial homeostatic disruption to inflammatory and immune outcomes.Biogerontology · 2026Review
- A synergistic cascade nanoreactor breaks bladder cancer chemoresistance: Synergizing cholesterol metabolism reprogramming with cGAS-STING-mediated metallotherapy.Materials today. Bio · 2026Article
- Exercise-induced lysosomal adaptations in skeletal muscle.Sports medicine and health science · 2026Review
- Review
- cGAS-STING axis: A central regulator of neural homeostasis and neuroinflammatory pathogenesis.Neural regeneration research · 2026Article
- Review
- Crosstalk collapse: mitochondria-centric organelle network disruption in ovarian aging.Cell communication and signaling : CCS · 2026Review
- Biomimetic nanoplatforms modulating mitochondrial pathways in IVDD.Journal of nanobiotechnology · 2026Article
- Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice.Nucleic acids research · 2026Article
- Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting mScience advances · 2026Article
- Article
- Targeting Mitochondria in Aging-Related Diseases: Therapeutic Potential and Obstacles.MedComm · 2026Review
- Menaquinone-7 alleviates mitochondrial dysfunction and senescence in senile osteoporosis by targeting the PINK1-mediated mitophagy via PXR/ERK/CREB signaling pathway.Journal of pharmaceutical analysis · 2026Article
- Mitochondrial drivers of stem cell aging and inflammaging.npj aging · 2026Review
- Targeting VDAC1 to protect against mitochondria-linked cell death pathways: apoptosis, pyroptosis, ferroptosis, and associated diseases.Apoptosis : an international journal on programmed cell death · 2026Article
- Endothelial NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mitochondrial DNA as a driver of inflammation via the cGAS-STING pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Cellular Senescence in Skeletal Muscle Aging.Endocrinology and metabolism (Seoul, Korea) · 2026Review
- The cGAS-STING pathway in senescence and aging-related diseases: mechanisms and therapeutic opportunities.Cell communication and signaling : CCS · 2026Review
- The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases.Exploration (Beijing, China) · 2026Review
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Authors and funding
14 authors.
Ying Li *School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China.
Jie Cui *School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China.
Lei LiuSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China.
William S HambrightCenter for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, CO, USA.
Yutai GanSchool of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, China.
Yajun ZhangSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China.
Shifeng RenSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China.
Xianlin YueSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China.
Liwei ShaoSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China.
Yan CuiDepartment of Orthopaedic Surgery, University of Texas Health Science Center, Houston, TX, USA.
Johnny HuardCenter for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, CO, USA.
Yanling MuSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China. muyanling@sdfmu.edu.cn.
Qingqiang YaoSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China. qqyao@sdfmu.edu.cn.
Xiaodong MuSchool of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan, Shandong, China. muxiaodong@sdfmu.edu.cn.ORCID 0000-0002-0362-0083
Funding
Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2022MC025
Abstract
The mechanism regulating cellular senescence of postmitotic muscle cells is still unknown. cGAS-STING innate immune signaling was found to mediate cellular senescence in various types of cells, including postmitotic neuron cells, which however has not been explored in postmitotic muscle cells. Here by studying the myofibers from Zmpste24
Indexed as
Cellular SenescenceDNA, MitochondrialMembrane ProteinsNucleotidyltransferasesAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansMetalloendopeptidasesMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitophagyMuscle CellsProgeriaSignal TransductioncGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialMembrane ProteinsMetalloendopeptidasesNucleotidyltransferasesSting1 protein, mouseSTING ProteinVoltage-Dependent Anion Channel 1Zmpste24 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.