Evidence map›Paper›PMID 39038938›Full record

ArticleBriefings in bioinformatics2024

Precision probiotics supplement strategy in aging population based on gut microbiome composition.

Yi-Fang Chuang, Kang-Chen Fan, Yin-Yuan Su, Ming-Fong Wu, Yen-Ling Chiu, Yi-Chien Liu, Chen-Ching Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Briefings in bioinformatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi-Fang ChuangSchool of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan.ORCID 0000-0002-5421-9855
Kang-Chen FanSchool of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan.ORCID 0009-0000-1931-0226
Yin-Yuan SuInstitute of Biomedical Informatics, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan.ORCID 0000-0002-2934-9797
Ming-Fong WuInstitute of Biomedical Informatics, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan.ORCID 0009-0007-4035-8065
Yen-Ling ChiuDepartment of Medical Research, Far Eastern Memorial Hospital, No. 21, Sec. 2, Nanya S. Rd., Banqiao Dist., New Taipei City 220216, Taiwan.ORCID 0000-0003-4504-5571
Yi-Chien LiuDepartment of Neurology, Cardinal Tien Hospital, No. 362, Zhongzheng Rd., Xindian Dist., New Taipei City 231009, Taiwan.ORCID 0000-0003-2579-740X
Chen-Ching LinInstitute of Biomedical Informatics, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304, Taiwan.ORCID 0000-0002-7831-7855

Funding

FEMH-NYCU Joint Research Program NYCU-FEMH 112DN11Ministry of Health and Welfare MOHW111-TDU-B-221-114007Ministry of Science and Technology MOST 110-2321-B-418Taiwan National Science and Technology Council
6 · The paper itself

Abstract

With the increasing prevalence of age-related chronic diseases burdening healthcare systems, there is a pressing need for innovative management strategies. Our study focuses on the gut microbiota, essential for metabolic, nutritional, and immune functions, which undergoes significant changes with aging. These changes can impair intestinal function, leading to altered microbial diversity and composition that potentially influence health outcomes and disease progression. Using advanced metagenomic sequencing, we explore the potential of personalized probiotic supplements in 297 older adults by analyzing their gut microbiota. We identified distinctive Lactobacillus and Bifidobacterium signatures in the gut microbiota of older adults, revealing probiotic patterns associated with various population characteristics, microbial compositions, cognitive functions, and neuroimaging results. These insights suggest that tailored probiotic supplements, designed to match individual probiotic profile, could offer an innovative method for addressing age-related diseases and functional declines. Our findings enhance the existing evidence base for probiotic use among older adults, highlighting the opportunity to create more targeted and effective probiotic strategies. However, additional research is required to validate our results and further assess the impact of precision probiotics on aging populations. Future studies should employ longitudinal designs and larger cohorts to conclusively demonstrate the benefits of tailored probiotic treatments.

Indexed as

AgingDietary SupplementsGastrointestinal MicrobiomeProbioticsAgedAged, 80 and overBifidobacteriumFemaleHumansLactobacillusMaleMetagenomicsMiddle Agedconsensus clusteringgut microbiomemetagenomicsnon-negative matrix factorizationolder adultsprecision probiotics

Identifiers

PMID39038938
PMCPMC11262831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.