ArticleGenome research2024
Global compositional and functional states of the human gut microbiome in health and disease.
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Article in Genome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed.
- Temporal dynamics of gut biosynthetic gene clusters link persistent colonization and engraftment in fecal microbiota transplantation.Gut microbes · 2026Article
- Gut microbiome and metabolic health: mechanisms and precision interventions.Gut microbes · 2026Review
- Sex differences in the gut microbiome and related metabolites: role in cardiometabolic disease.Gut microbes · 2026Review
- Systems engineering of engineered live biotherapeutics: A discovery-to-translation framework for streamlining microbiome therapeutic development.Journal of controlled release : official journal of the Controlled Release Society · 2026Review
- Advancing Whole-Person Health through Informatics: A Narrative Review of Knowledge Resources for Complementary and Integrative Health.The Journal of nutrition · 2026Review
- The Metabolic Calibration of Female Immune Plasticity: From X-Linked Vulnerability to Precision Metabotyping.Biology · 2026Review
- Detection of Fungal Translocation in Patients With Alcohol Use Disorder Using a Real-Time PCR Assay.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Suprathreshold non-volatile flavour perception is associated with multiple species rather than any single species via bacterial metabolism.Journal of oral microbiology · 2026Article
- A data-driven universal gut microbiome health assessment: a machine learning framework trained on large metagenomic data.Frontiers in microbiology · 2026Article
- Fedflow: cloud orchestration for federated learning with the FeatureCloud platform.Bioinformatics advances · 2026Article
- Short-chain fructo-oligosaccharides modulate gut microbiota composition and metabolism: dose-response assessment in anGut microbes reports · 2026Article
- Cohort-specific determinants of donor strain engraftment following multi-donor faecal microbiota transplantation in two randomised clinical trials.Gut microbes · 2025Article
- Microbiome signatures of virulence in the oral-gut-brain axis influence Parkinson's disease and cognitive decline pathophysiology.Gut microbes · 2025Article
- The Role of the Gut Microbiome in Type 2 Diabetes Mellitus.International journal of molecular sciences · 2025Review
- HGMT: a database of human gut microbiota for tumors and immunotherapy response.Genome biology · 2025Article
- The soil-plant-human gut microbiome axis into perspective.Nature communications · 2025Review
- Recent advances in therapeutic probiotics: insights from human trials.Clinical microbiology reviews · 2025Review
- Nitrate supplementation affects taste by changing the oral metabolome and microbiome.NPJ biofilms and microbiomes · 2025Article
- Article
- The human microbiome in clinical translation: from bench to bedside.Frontiers in microbiology · 2025Review
Corrections and comments
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Authors and funding
33 authors.
Sunjae Lee *Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Theo Portlock *Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, SE-171 21, Sweden.
Emmanuelle Le Chatelier *University Paris-Saclay, INRAE, MetaGenoPolis, 78350 Jouy-en-Josas, France.
Fernando Garcia-Guevara *Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Frederick ClasenCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Florian Plaza OñateUniversity Paris-Saclay, INRAE, MetaGenoPolis, 78350 Jouy-en-Josas, France.
Nicolas PonsUniversity Paris-Saclay, INRAE, MetaGenoPolis, 78350 Jouy-en-Josas, France.
Neelu BegumCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Azadeh HarzandiCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Ceri ProffittCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Dorines RosarioCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Stefania VagaCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Junseok ParkDepartment of Bio and Brain Engineering, KAIST, Yuseong-gu, Daejeon 305-701, Republic of Korea.ORCID 0000-0003-2312-9440
Kalle von FeilitzenScience for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, SE-171 21, Sweden.
Fredric JohanssonScience for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, SE-171 21, Sweden.
Cheng ZhangScience for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, SE-171 21, Sweden.
Lindsey A EdwardsCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Vincent LombardINRAE, USC1408 Architecture et Fonction des Macromolécules Biologiques (AFMB), Marseille 13288, France.
Franck GauthierUniversity Paris-Saclay, INRAE, MetaGenoPolis, 78350 Jouy-en-Josas, France.
Claire J StevesDepartment of Twin Research & Genetic Epidemiology, King's College London, London WC2R 2LS, United Kingdom.
David Gomez-CabreroCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.ORCID 0000-0003-4186-3788
Bernard HenrissatDepartment of Biological Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Doheon LeeDepartment of Bio and Brain Engineering, KAIST, Yuseong-gu, Daejeon 305-701, Republic of Korea.
Lars EngstrandCentre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, 171 65 Stockholm, Sweden.
Debbie L ShawcrossInstitute of Liver Studies, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King's College London, London SE5 9NU, United Kingdom.
Gordon ProctorCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Mathieu AlmeidaUniversity Paris-Saclay, INRAE, MetaGenoPolis, 78350 Jouy-en-Josas, France.
Jens NielsenDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.
Adil MardinogluCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
David L MoyesCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom.
Stanislav Dusko EhrlichUniversity Paris-Saclay, INRAE, MetaGenoPolis, 78350 Jouy-en-Josas, France.
Mathias UhlenScience for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, SE-171 21, Sweden; mathias.uhlen@scilifelab.se saeed.shoaie@kcl.ac.uk.ORCID 0000-0002-4858-8056
Saeed ShoaieCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, SE1 9RT, United Kingdom; mathias.uhlen@scilifelab.se saeed.shoaie@kcl.ac.uk.
Funding
Wellcome Trust
Abstract
The human gut microbiota is of increasing interest, with metagenomics a key tool for analyzing bacterial diversity and functionality in health and disease. Despite increasing efforts to expand microbial gene catalogs and an increasing number of metagenome-assembled genomes, there have been few pan-metagenomic association studies and in-depth functional analyses across different geographies and diseases. Here, we explored 6014 human gut metagenome samples across 19 countries and 23 diseases by performing compositional, functional cluster, and integrative analyses. Using interpreted machine learning classification models and statistical methods, we identified
Indexed as
Gastrointestinal MicrobiomeMetagenomeMetagenomicsBacteriaFusobacterium nucleatumHumansMachine Learning
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.