Evidence map›Paper›PMID 39038846›Full record

ReviewCold Spring Harbor perspectives in biology2025

Interneuron Diversity: How Form Becomes Function.

Natalia V De Marco García, Gord Fishell

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Natalia V De Marco GarcíaCenter for Neurogenetics, Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York 10021, USA nad2018@med.cornell.edu gordon_fishell@hms.harvard.edu.
Gord FishellHarvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, Massachusetts 02115, USA nad2018@med.cornell.edu gordon_fishell@hms.harvard.edu.

Funding

The role of genetic and activity dependent cues in the generation of 5HT3aR interneuron diversityP01NS074972 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MACHOLD, ROBERT P · 2012 to 2023
$15.5M
Systematic identification of enhancers to target the breadth of excitatory and inhibitory neuronal cell types in the cerebral cortexUF1MH130701 · NIMH · BROAD INSTITUTE, INC. · PI ARLOTTA, PAOLA, DEVERMAN, BENJAMIN E · 2022 to 2022
$10.7M
The Development and Integration of Early Born SST-Expressing Interneurons in the CortexR01NS081297 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORDON J FISHELL · 2012 to 2026
$6.6M
Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species.UH3MH120096 · NIMH · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E, FISHELL, GORDON J · 2023 to 2024
$4.7M
Neural Mechanism for the assembly of GABAergic in the cerebral cortexR01MH110553 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI Natalia Vanesa De Marco Garcia · 2016 to 2026
$4.2M
The molecular and cellular basis of cortical interneuron divergenceR37MH071679 · NIMH · HARVARD MEDICAL SCHOOL · PI GORDON J FISHELL · 2022 to 2026
$4.1M
A Circuit Mechanism for the Development of Cortico-cortical ConnectivityR01NS116137 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE MARCO GARCIA, NATALIA VANESA · 2020 to 2024
$2.6M
GABAergic Interneuron Dysfunction in Developing Cortical Circuits Underlying Autism Spectrum DisordersR01MH125006 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE MARCO GARCIA, NATALIA VANESA, RAJADHYAKSHA, ANJALI M · 2021 to 2025
$2.1M
NIMH NIH HHS R01 MH110553NIMH NIH HHS R01 MH125006NIMH NIH HHS R37 MH071679NIMH NIH HHS UF1 MH130701NIMH NIH HHS UH3 MH120096NINDS NIH HHS P01 NS074972NINDS NIH HHS R01 NS081297NINDS NIH HHS R01 NS116137
6 · The paper itself

Abstract

A persistent question in neuroscience is how early neuronal subtype identity is established during the development of neuronal circuits. Despite significant progress in the transcriptomic characterization of cortical interneurons, the mechanisms that control the acquisition of such identities as well as how they relate to function are not clearly understood. Accumulating evidence indicates that interneuron identity is achieved through the interplay of intrinsic genetic and activity-dependent programs. In this work, we focus on how progressive interactions between interneurons and pyramidal cells endow maturing interneurons with transient identities fundamental for their function during circuit assembly and how the elimination of transient connectivity triggers the consolidation of adult subtypes.

Indexed as

InterneuronsAnimalsHumansPyramidal Cells

Identifiers

PMID39038846
PMCPMC11751130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.