Evidence map›Paper›PMID 39038700›Full record

ArticleContemporary clinical trials2024

Remotely-delivered exercise training program for improving physical and cognitive functions among older adults with multiple sclerosis: Protocol for an NIH stage-I randomized controlled trial.

Peixuan Zheng, Shane A Phillips, Jennifer Duffecy, Sydney R DeJonge, Noah G DuBose, Robert W Motl

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05930821 (Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05930821 naactive not recruitingnot on this map

Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2023 to 2025Enrolled51ConditionsOlder Adults, Multiple Sclerosis, Cognitive Impairment, Walking ImpairmentArmsAerobic and Resistance Exercise Program (GEMS program), Flexibility and Stretching Program (FLEX-MS program)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peixuan ZhengDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, United States. Electronic address: pxzheng@uic.edu.
Shane A PhillipsDepartment of Physical Therapy, University of Illinois Chicago, Chicago, IL, United States.
Jennifer DuffecyDepartment of Psychiatry, University of Illinois Chicago, Chicago, IL, United States.
Sydney R DeJongeDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, United States.
Noah G DuBoseDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, United States.
Robert W MotlDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, United States.

Funding

Pilot CoreP30AG022849 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Tanvi Bhatt, DAVID X MARQUEZ · 2003 to 2026
$14.7M
NIA NIH HHS P30 AG022849
6 · The paper itself

Abstract

backgroundOlder adults with multiple sclerosis (MS) present with low physical activity participation, cognitive and ambulatory dysfunctions, and compromised quality of life (QOL).

objectiveWe propose a NIH Stage-I, randomized controlled trial (RCT) that examines the feasibility and efficacy of a 16-week theory-based, remotely-delivered, exercise training program for improving cognitive and physical functions in older adults with MS who have moderate mobility disability without severe cognitive impairment.

methodsThis Stage-I study utilizes a parallel-group RCT design. Participants (N = 50; age ≥ 50 years) will be randomly assigned into exercise training (combined aerobic and resistance exercise) or active control (flexibility and stretching) conditions. The conditions will be undertaken within a participant's home/community over a 16-week period, and monitored remotely and supported by Zoom-based chats guided by social cognitive theory (SCT) via a behavioral coach. Participants will receive training manuals and equipment, one-on-one behavioral coaching, action-planning calendars, self-monitoring logs, and SCT-based newsletters. The primary outcomes include feasibility (e.g., recruitment and retention rates), exercise behavior and physical activity; other outcomes include physical function (lower-extremity function, mobility, walking), cognition (processing speed, learning and memory, executive function), MS symptoms, QOL, and vascular function. We will collect outcome data at baseline (Week 0), post-intervention (Week 16), and follow-up (Week-32). Data analysis will follow intent-to-treat principles using linear mixed-effects models. DISCUSSION: This Stage-I trial adopts an innovative approach for exercise training via telerehabilitation and is convenient and accessible for older adults with MS. If successful, the study will provide foundations for future research using remotely-delivered exercise intervention for managing the consequences of aging with MS. TRIAL REGISTRATION NUMBER: NCT05930821.

Indexed as

CognitionExercise TherapyMultiple SclerosisQuality of LifeAgedCognitive DysfunctionExerciseFeasibility StudiesFemaleHumansMaleMiddle AgedMobility LimitationRandomized Controlled Trials as TopicResistance TrainingAgingCognitionExerciseHome-basedMultiple sclerosisRehabilitationWalking

Identifiers

PMID39038700
PMCPMC12039312

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.