Evidence map›Paper›PMID 39038228›Full record

ArticleInflammatory bowel diseases2025

Risankizumab Is Effective for The Management of Crohn's Disease of the Pouch.

Maia Kayal, Elizabeth A Spencer, Matthew Smyth, Laura Raffals, Taha Qazi, Parakkal Deepak, Poonam Beniwal-Patel, Shannon Chang, Peter Higgins, Raymond K Cross and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammatory bowel diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07756359 (Efficacy of the Dual GIP - GLP-1 Receptor Agonist Tirzepatide in Patients With an Ileal Pouch-anal Anastomosis), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07756359 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy of the Dual GIP - GLP-1 Receptor Agonist Tirzepatide in Patients With an Ileal Pouch-anal Anastomosis (IPAA) and Chronic High Bowel Frequency (I8F-NS-X008)

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2026 to 2027Enrolled20ConditionsPouch, Ileal, Pouches, Ileoanal, Bowel Diseases, InflammatoryArmsTirzepatide, Loperamide, Diphenoxylate/Atropine
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Managing Refractory Pouchitis: Which Biologic Is Best?Digestive diseases and sciences · 2026
    Article
  2. Article
  3. Interleukin-23 Inhibitors in Inflammatory Bowel Disease.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  4. Article
  5. Onset of pouchitis after colectomy for ulcerative colitis: reducing the risk.Expert review of gastroenterology & hepatology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Maia KayalDivision of Gastroenterology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9640-950X
Elizabeth A SpencerDivision of Pediatric Gastroenterology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6787-1164
Matthew SmythDivision of Pediatric Gastroenterology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Laura RaffalsDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-5267-2592
Taha QaziDivision of Gastroenterology, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-6770-9055
Parakkal DeepakDivision of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-3436-9784
Poonam Beniwal-PatelDivision of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA.
Shannon ChangDivision of Gastroenterology and Hepatology, NYU Langone Health, New York, NY, USA.
Peter HigginsDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
Raymond K CrossDivision of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD, USA.
Chelsea AndersonCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Millie LongCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Hans H HerfarthCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Marla C DubinskyDivision of Pediatric Gastroenterology, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-4968-5795
Edward L BarnesCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTHONY BLIKSLAGER · 1985 to 2026
$30.5M
Treatment Approaches and Outcomes in Pouch-related Disorders after Colectomy for Ulcerative ColitisK23DK127157 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARNES, EDWARD · 2021 to 2025
$1.0M
Characterizing the Biologic Evolution of Crohn's Disease Like Pouch Inflammation in Ulcerative Colitis Patients After Restorative Proctocolectomy with Ileal Pouch Anal AnastomosisK23DK127241 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maia Kayal · 2022 to 2026
$955k
Career Development Award K23DK127241-01A1CCF 614963NIDDK NIH HHS K23 DK127157NIDDK NIH HHS K23 DK127241NIDDK NIH HHS P30 DK034987NIH HHS K23DK127157
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39038228
PMCPMC11879156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.