Evidence map›Paper›PMID 39038224›Full record

ArticleLaboratory medicine2025

Therapeutic plasma exchange for hyperviscosity syndrome in IgA multiple myeloma.

Nalan Yurtsever, Thomas C Binns, Jeanne E Hendrickson, Christopher A Tormey, Edward S Lee

Abstract readCase Reports
In one paragraph

Article in Laboratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nalan YurtseverDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, US.ORCID 0000-0001-7807-6046
Thomas C BinnsDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, US.ORCID 0000-0003-1246-8957
Jeanne E HendricksonDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, US.ORCID 0000-0002-7928-3132
Christopher A TormeyDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, US.
Edward S LeeDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, US.ORCID 0000-0003-1723-4463

Funding

IMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1M
NHLBI NIH HHS T32 HL007974
6 · The paper itself

Abstract

Hyperviscosity syndrome (HVS) is defined as the symptomatic presentation of increased blood thickness due to various clinical conditions such as hypergammaglobulinemia. HVS secondary to immunoglobulin (Ig)A multiple myeloma has been infrequently reported. Although the efficiency of IgM or IgG removal by therapeutic plasma exchange (TPE) is well described, the efficiency of IgA removal by TPE is not as well known. Here, we describe a case of HVS due to IgA myeloma in a patient who received 2 TPE treatments, with subsequent symptomatic improvement as well as decrease in IgA and viscosity levels.

Indexed as

Blood ViscosityImmunoglobulin AMultiple MyelomaPlasma ExchangeAgedHumansHypergammaglobulinemiaMaleMiddle AgedSyndromeImmunoglobulin AhyperviscosityIgAIgGplasma exchangeplasmapheresis

Identifiers

PMID39038224
PMCPMC13396130

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.