Evidence map›Paper›PMID 39037763›Full record

ArticleeLife2024

Recombinant origin and interspecies transmission of a HERV-K(HML-2)-related primate retrovirus with a novel RNA transport element.

Zachary H Williams, Alvaro Dafonte Imedio, Lea Gaucherand, Derek C Lee, Salwa Mohd Mostafa, James P Phelan, John M Coffin, Welkin E Johnson

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zachary H WilliamsDepartment of Biology, Boston College, Boston, United States.ORCID https://orcid.org/0000-0002-5091-2089
Alvaro Dafonte ImedioDepartment of Biology, Boston College, Boston, United States.
Lea GaucherandMolecular Microbiology Program, Tufts University Graduate School of Biomedical Sciences, Boston, United States.ORCID https://orcid.org/0000-0002-4477-1021
Derek C LeeDepartment of Biology, Boston College, Boston, United States.
Salwa Mohd MostafaDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, United States.
James P PhelanMolecular Microbiology Program, Tufts University Graduate School of Biomedical Sciences, Boston, United States.
John M CoffinMolecular Microbiology Program, Tufts University Graduate School of Biomedical Sciences, Boston, United States.
Welkin E JohnsonDepartment of Biology, Boston College, Boston, United States.ORCID https://orcid.org/0000-0001-5991-5414

Funding

Retrovirus Evolution and CancerR35CA200421 · NCI · TUFTS UNIVERSITY BOSTON · PI COFFIN, JOHN M · 2016 to 2022
$6.5M
Cross-Species transmission and adaptation of primate lentivirusesR01AI083118 · NIAID · HARVARD MEDICAL SCHOOL · PI JOHNSON, WELKIN E · 2009 to 2019
$4.0M
Human endogenous provirus inhibition of HIV replicationR01AI184043 · NIAID · TUFTS UNIVERSITY BOSTON · PI JOHN M COFFIN · 2024 to 2026
$2.1M
Simple Retroviruses and Resistance to TetherinR21AI136074 · NIAID · BOSTON COLLEGE · PI JOHNSON, WELKIN E · 2018 to 2019
$391k
National Institute of Allergy and Infectious Diseases AI083118National Institute of Allergy and Infectious Diseases AI136074NCI NIH HHS R35 CA200421NCI NIH HHS R35CA200421NIAID NIH HHS R01 AI184043
6 · The paper itself

Abstract

HERV-K(HML-2), the youngest clade of human endogenous retroviruses (HERVs), includes many intact or nearly intact proviruses, but no replication competent HML-2 proviruses have been identified in humans. HML-2-related proviruses are present in other primates, including rhesus macaques, but the extent and timing of HML-2 activity in macaques remains unclear. We have identified 145 HML-2-like proviruses in rhesus macaques, including a clade of young, rhesus-specific insertions. Age estimates, intact open reading frames, and insertional polymorphism of these insertions are consistent with recent or ongoing infectious activity in macaques. 106 of the proviruses form a clade characterized by an ~750 bp sequence between

Indexed as

Endogenous RetrovirusesMacaca mulattaProvirusesRecombination, GeneticAnimalsHumansPhylogenyRetroviridae InfectionsRNA, ViralRNA, Viralendogenous retrovirusevolutionary biologyhumaninfectious diseasemicrobiologyrecombinationrhesus macaqueRNA exportviral evolutionviruseszoonosis

Identifiers

PMID39037763
PMCPMC11379458

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.