Evidence map›Paper›PMID 39037689›Full record

ArticleCurrent environmental health reports2024

Exposure to Synthetic Endocrine-Disrupting Chemicals in Relation to Maternal and Fetal Sex Steroid Hormones: A Scoping Review.

Megan C Hansel, Abigail M Rosenberg, Carolyn W Kinkade, Camila Capurro, Zorimar Rivera-Núñez, Emily S Barrett

Abstract readScoping Review
In one paragraph

Article in Current environmental health reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Bisphenol S and female reproductive toxicity: a scoping review of human studies.Journal of exposure science & environmental epidemiology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Megan C HanselDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.
Abigail M RosenbergDepartment of Obstetrics and Gynecology, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, NY, 14642, USA.
Carolyn W KinkadeEnvironmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.
Camila CapurroDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.
Zorimar Rivera-Núñez *Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.
Emily S Barrett *Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. esb104@eohsi.rutgers.edu.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
Mycoestrogen Disposition and Activity in the PlacentaF31ES029794 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI GORCZYCA, LUDWIK JANUSZ · 2018 to 2019
$62k
NIEHS NIH HHS F31ES029794NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30ES005022Rutgers School of Public Health 21PHirst Century Pre-Doctoral Fellowship
6 · The paper itself

Abstract

purpose of reviewMany synthetic endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment and highly detected among pregnant people. These chemicals may disrupt maternal and/or fetal sex steroid hormones, which are critical to pregnancy maintenance and fetal development. Here, we review the epidemiological literature examining prenatal exposure to common synthetic EDCs in relation to maternal and fetal sex steroid hormones. RECENT

findingsWe performed a literature search using PubMed, SCOPUS, and Embase, ultimately identifying 29 articles for full review. Phenols, parabens, and persistent organic pollutants generally showed inverse associations with androgens, estrogens, and progesterone. Phthalates and per-and polyfluoroalkyl substances tended to be inversely associated with progesterone, while evidence regarding androgens and estrogens was mixed. Inconsistent, but noteworthy, differences by fetal sex and timing of exposure/outcome were observed. Overall, the literature suggests EDCs may disrupt maternal and fetal sex steroid activity, though findings are mixed. Given the pervasive, high-volume production of these synthetic chemicals and the critical functions sex steroid hormones play during gestation, additional research is warranted.

Indexed as

Endocrine DisruptorsGonadal Steroid HormonesFemaleFetusHumansMaternal ExposurePersistent Organic PollutantsPhthalic AcidsPregnancyEndocrine DisruptorsGonadal Steroid HormonesPersistent Organic PollutantsPhthalic AcidsAndrogensEndocrine-disrupting chemicalsEstrogensPregnancySex steroid hormonesSynthetic chemicals

Identifiers

PMID39037689
PMCPMC11324767

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.