Evidence map›Paper›PMID 39037448›Full record

SynthesisLangenbeck's archives of surgery2024

Safety and effectivity of Kono-S anastomosis in Crohn's patients: a systematic review and Meta-analysis.

Marionna Cathomas, Baraa Saad, Stephanie Taha-Mehlitz, Dilip K Vankayalapati, Nour El Ghazal, Mohammed Majd Mourad, Niklas Ortlieb, Christian A Than, Emanuel Burri, Christine Glaser and 5 more

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Langenbeck's archives of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07772037 (Oxidative Epithelial Injury After Ileocolic Resection a Retrospective Pilot Study Comparing Kono-S Versus Conventional Anastomotic Configurations Using Intestinal Epithelial GPX4 Expression.), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07772037 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Oxidative Epithelial Injury After Ileocolic Resection a Retrospective Pilot Study Comparing Kono-S Versus Conventional Anastomotic Configurations Using Intestinal Epithelial GPX4 Expression.

TypeobservationalSponsorEast Kent Hospitals University NHS Foundation TrustRan2026 to 2027Enrolled25ConditionsChrohn's Disease
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Predictors of conversion and outcomes after conversion in laparoscopic redo ileocolic resection for Crohn's disease.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marionna Cathomas *Department of Surgery, Cantonal Hospital Baselland, Rheinstrasse 26, Liestal, 4410, Switzerland.
Baraa Saad *School of Medicine, St George's University of London, London, SW17 0RE, UK.
Stephanie Taha-MehlitzClarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland.
Dilip K VankayalapatiStoke Mandeville Hospital, Buckinghamshire NHS Trust, Oxford Thames Valley, Aylesbury, UK.
Nour El GhazalSchool of Medicine, St George's University of London, London, SW17 0RE, UK.
Mohammed Majd MouradSchool of Medicine, St George's University of London, London, SW17 0RE, UK.
Niklas OrtliebMedoc Swiss GMBH, Healthcare management, Basel, Switzerland.
Christian A ThanSchool of Biomedical Sciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.
Emanuel BurriDepartment of Gastroenterology and Hepatology, Medical University Clinic, Cantonal Hospital Baselland, Liestal, Switzerland.
Christine GlaserDepartment of Surgery, Cantonal Hospital Baselland, Rheinstrasse 26, Liestal, 4410, Switzerland.
Andres HeiglDepartment of Surgery, Cantonal Hospital Baselland, Rheinstrasse 26, Liestal, 4410, Switzerland.
Katerina NeumannDivision of General Surgery, Dalhousie University, Nova scotia, Halifax, Canada.
Michael D HonakerDepartment of Surgery, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Anas Taha *Department of Surgery, Cantonal Hospital Baselland, Rheinstrasse 26, Liestal, 4410, Switzerland. anas.taha@unibas.ch.
Robert Rosenberg *Department of Surgery, Cantonal Hospital Baselland, Rheinstrasse 26, Liestal, 4410, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeKono-S anastomosis, an antimesenteric, functional, end-to-end handsewn anastomosis, was introduced in 2011. The aim of this meta-analysis is to evaluate the safety and effectivity of the Kono-S technique.

methodsA comprehensive search of MEDLINE (PubMed), Embase (Elsevier), Scopus (Elsevier), and Cochrane Central (Ovid) from inception to August 24th, 2023, was conducted. Studies reporting outcomes of adults with Crohn's disease undergoing ileocolic resection with subsequent Kono-S anastomosis were included. PRISMA and Cochrane guidelines were used to screen, extract and synthesize data. Primary outcomes assessed were endoscopic, surgical and clinical recurrence rates, as well as complication rates. Data were pooled using random-effects models, and heterogeneity was assessed with I² statistics. ROBINS-I and ROB2 tools were used for quality assessment.

results12 studies involving 820 patients met the eligibility criteria. A pooled mean follow-up time of 22.8 months (95% CI: 15.8, 29.9; I

conclusionsDespite limited and heterogenous data, patients undergoing Kono-S anastomosis had low rates of surgical recurrence and anastomotic leakage with moderate rates of endoscopic recurrence, clinical recurrence and complications rate.

Indexed as

Anastomosis, SurgicalCrohn DiseaseColonHumansIleumPostoperative ComplicationsRecurrenceBowel resectionCrohn’s diseaseFunctional end to end anastomosisKono-S anastomosis

Identifiers

PMID39037448
PMCPMC11263246

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.