Evidence map›Paper›PMID 39037381›Full record

ArticleLupus2024

Childhood-onset systemic lupus erythematosus: A descriptive and comparative study of clinical, laboratory, and treatment characteristics in two populations.

Gülşah Kavrul Kayaalp, Deren Esencan, Vafa Guliyeva, Selen Duygu Arık, Şeyma Türkmen, Sezgin Şahin, Yelda Bilginer, Özgür Kasapçopur, Betül Sözeri, Seza Özen and 2 more

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gülşah Kavrul KayaalpDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University Faculty of Medicine, Istanbul, Turkey.ORCID 0000-0001-7490-7076
Deren EsencanDivision of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Vafa GuliyevaDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Selen Duygu ArıkDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Şeyma TürkmenDivision of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Umraniye Research and Training Hospital, Istanbul, Turkey.
Sezgin ŞahinDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID 0000-0002-5365-3457
Yelda BilginerDivision of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Özgür KasapçopurDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University-Cerrahpaşa, Istanbul, Turkey.ORCID 0000-0002-1125-7720
Betül SözeriDivision of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Umraniye Research and Training Hospital, Istanbul, Turkey.
Seza ÖzenDivision of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Nuray Aktay AyazDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University Faculty of Medicine, Istanbul, Turkey.ORCID 0000-0003-3594-7387
Amr H SawalhaDivision of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-3884-962X

Funding

Role of DNA methylation in lupusR01AI097134 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Amr H Sawalha · 2013 to 2026
$4.5M
NIAID NIH HHS R01 AI097134
6 · The paper itself

Abstract

objectiveThe aim of this study was to characterize childhood-onset systemic lupus erythematosus (SLE) in two large cohorts from Turkey and the United States.

methodsPatients diagnosed with childhood-onset SLE who fulfilled the 1997 American College of Rheumatology classification criteria for SLE from four reference centers in Turkey and the University of Pittsburgh School of Medicine in the United States were included in this study. A comparative analysis was conducted to evaluate the similarities and differences in clinical and laboratory features, damage accrual, and treatment experiences between the two populations.

resultsA total of 174 patients with childhood-onset SLE were included in this study (108 patients from Turkey and 66 patients from the United States). The female-to-male ratio was similar between the two cohorts (∼3:1,

conclusionThis study provides detailed clinical and laboratory features of childhood-onset SLE in two independent and geographically divergent cohorts. Our findings suggest an earlier age of disease onset and a higher prevalence of kidney involvement in Turkish patients. Differences in treatment approaches were also noted. However, damage accrual related to SLE does not appear to be different between the two patient populations.

Indexed as

Age of OnsetImmunosuppressive AgentsLupus Erythematosus, SystemicAdolescentAntibodies, Monoclonal, HumanizedChildChild, PreschoolCohort StudiesCyclophosphamideFemaleHumansMaleTurkeyUnited StatesAntibodies, Monoclonal, HumanizedbelimumabCyclophosphamideImmunosuppressive Agentscharacteristicschildhood-onsetdamageLupuspediatrictreatment

Identifiers

PMID39037381
PMCPMC11405132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.