Evidence map›Paper›PMID 39037068›Full record

ArticleLab on a chip2024

Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing.

Rohan Palanki, Emily L Han, Amanda M Murray, Rohin Maganti, Sophia Tang, Kelsey L Swingle, Dongyoon Kim, Hannah Yamagata, Hannah C Safford, Kaitlin Mrksich and 2 more

Abstract read
In one paragraph

Article in Lab on a chip, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Nanoparticle Carriers: A New Era of Precise CRISPR/Cas9 Gene Editing.MicroRNA (Shariqah, United Arab Emirates) · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Rheumatoid Arthritis Therapy Based on B Cells.Drug design, development and therapy · 2025
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rohan PalankiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.ORCID http://orcid.org/0000-0001-5168-5634
Emily L HanDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.
Amanda M MurrayDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.
Rohin MagantiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.
Sophia TangDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.
Kelsey L SwingleDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.ORCID http://orcid.org/0000-0001-8475-9206
Dongyoon KimDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.
Hannah YamagataDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.ORCID http://orcid.org/0000-0002-9525-7102
Hannah C SaffordDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.ORCID http://orcid.org/0000-0002-2512-8153
Kaitlin MrksichDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.ORCID http://orcid.org/0009-0008-7971-2129
William H PeranteauCenter for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. peranteauw@chop.edu.
Michael J MitchellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. mjmitch@seas.upenn.edu.ORCID http://orcid.org/0000-0002-3628-2244

Funding

In utero gene editing to cure a metabolic liver diseaseR01DK123049 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI PERANTEAU, WILLIAM H. · 2020 to 2024
$3.7M
In utero CRISPR-mediated gene editing to cure congenital monogenic disordersDP2HL152427 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI PERANTEAU, WILLIAM H. · 2019 to 2019
$2.6M
A data-driven drug delivery (4D) platform for probing and treating the chemoresistant bone marrow microenvironmentDP2TR002776 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL, MICHAEL J · 2018 to 2018
$2.4M
Ionizable Lipid Nanoparticles for Fetal Lung TargetingF30HL162465 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PALANKI, ROHAN · 2022 to 2025
$178k
NCATS NIH HHS DP2 TR002776NHLBI NIH HHS DP2 HL152427NHLBI NIH HHS F30 HL162465NIDDK NIH HHS R01 DK123049
6 · The paper itself

Abstract

mRNA-based gene editing platforms have tremendous promise in the treatment of genetic diseases. However, for this potential to be realized

Indexed as

Gene EditingLipidsNanoparticlesAnimalsCRISPR-Cas SystemsExcipientsHumansLab-On-A-Chip DevicesLiposomesMiceExcipientsLipid NanoparticlesLipidsLiposomes

Identifiers

PMID39037068
PMCPMC11302771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.