ArticlePediatric transplantation2024
Acute Kidney Injury Requiring Dialysis After Pediatric Heart Transplant.
Article in Pediatric transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Acute Kidney Injury After Pediatric Heart Transplant: The Impact of Intraoperative Hemodynamics Using High-Fidelity Data.Pediatric cardiology · 2026Article
- Three and a Half Decades of Pediatric Heart Transplantation: Evolution of Surgical Practice and Outcomes at a High-Volume Centre.Journal of cardiovascular development and disease · 2026Article
- Early outcomes of pediatric heart transplantation: Impact of mechanical circulatory support and perioperative challenges. A single-center retrospective study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Review
- Perioperative anesthetic management in pediatric heart transplantation: a single-center descriptive study involving 27 patients.Frontiers in pediatrics · 2026Article
- Risk factors affecting mortality in pediatric heart transplantation: A comprehensive review of pre- and post-transplant contributors.JHLT open · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundAcute kidney injury (AKI) is a common complication of pediatric heart transplant, with a subset of patients developing severe AKI requiring dialysis (AKI-D). We aimed to identify the epidemiology, risk factors, and outcomes of postoperative AKI-D in pediatric heart transplant recipients.
methodsWe retrospectively identified all pediatric first-time, single-organ heart transplants at our institution from 2014 to 2022. Postoperative AKI was defined as AKI within 2 weeks of transplant. Unadjusted and adjusted logistic regression were used to identify characteristics associated with AKI-D, and unadjusted time-to-event analyses were used to determine the association between AKI-D and survival free of kidney failure.
resultsAmong 177 patients included, 116 (66%) developed postoperative AKI of any stage, including 13 (7%) who developed AKI-D with median time from transplant to dialysis initiation of 6 days (IQR 3-13). In adjusted models, increased cardiopulmonary bypass time (OR 1.19, 95% CI 1.04-1.37, per 15 min increase in bypass time) and higher weight at transplant were associated with higher odds of AKI-D, whereas patient demographics and pretransplant kidney function were not associated with AKI-D. AKI-D was associated with greater mortality during initial hospitalization (46% vs. 1%, p < 0.001) and a lower rate of survival free of kidney failure.
conclusionsThe incidence of AKI-D after pediatric heart transplant was 7%, with extended cardiopulmonary bypass time associated with postoperative AKI-D even in adjusted models. Further research is needed to improve the prediction and management of AKI-D in this population.
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