ReviewAdvances in ophthalmology practice and research
Complications of high myopia: An update from clinical manifestations to underlying mechanisms.
Review in Advances in ophthalmology practice and research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bidirectional Relationship Between Myopia and Mental Disorders.Depression and anxiety · 2025Pooled it
- Movement of central retinal vessel trunk and its correlation with lamina cribrosa pores movement after short-term intraocular pressure elevation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Axial Length to Corneal Curvature Ratio is Insufficient for Detecting Pseudomyopia in Children: A Multi-Cohort Study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- A Comparative Study of Atropine, Orthokeratology, and Combination Therapy for Axial Elongation in Children with Myopia.Journal of clinical medicine · 2026Article
- Trends in childhood myopia over a 5-year interval: Korea national health and nutrition examination survey 2016 and 2021.Japanese journal of ophthalmology · 2026Article
- Rapidly progressive bilateral lens abnormalities following cataract surgery in a highly myopic patient.BMC ophthalmology · 2026Article
- The Effect of Three-Dimensional Ocular Shape on Longitudinal Biometric Changes: A Six-Year Follow-Up Study.Translational vision science & technology · 2026Article
- Shared Genetic Architecture and Multidimensional Modifiable Correlates between Myopia and Retinal-Optic Nerve Diseases.Ophthalmology science · 2026Article
- Recurrent rhegmatogenous retinal detachment: incidence, established and emerging risk factors, and clinical outcomes.BMC ophthalmology · 2026Article
- Article
- Automated Optic Disc Tilt Classification in Fundus Photographs Using Segmentation and the Elliptical Ratio: External Clinical Validation Study.JMIR formative research · 2026Article
- Smart Nanodelivery for Eye-Brain Disorders: Synergistic CCL2 Neutralization and MMP9 Silencing Reverse Anxiety in High Myopia.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- School and family based myopia education associations with myopia prevalence in Hefei high school students in the post-COVID-19 period.Scientific reports · 2026Article
- Integrating Polygenic Risk and Ocular Phenotyping Reveals an Axial-Length-Dominant Mechanism in High and Extreme High Myopia.Ophthalmology science · 2026Article
- Sector-Specific Patterns of RNFL and Ganglion Cell Complex Thinning Across the Myopia Spectrum: A Cross-Sectional OCTA Study.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Associations Between Circulating Polyunsaturated Fatty Acids and Photoreceptor Measurement.Translational vision science & technology · 2026Article
- Multi-Granularity Mask-Guided Network: An Integrated AI Framework for Region-Level Segmentation and Grading of Cataract Subtypes on AS-OCT Images.Journal of clinical medicine · 2026Article
- Real-World Effectiveness of CARE-Based Spectacle Lenses for Myopia Control in a Turkish Pediatric Cohort.Vision (Basel, Switzerland) · 2026Article
- Routine blood tests and machine learning identify complications in high myopia.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: High myopia is one of the major causes of visual impairment and has an ever-increasing prevalence, especially in East Asia. It is characterized by excessive axial elongation, leading to various blinding complications that extend beyond mere refractive errors and persist immovably after refractive surgery, presenting substantial public health challenge. Main text: High myopia-related complications include lens pathologies, atrophic and tractional maculopathy, choroidal neovascularization, peripheral retinal degenerations and retinal detachment, and glaucoma and heightened susceptibility to intraocular pressure (IOP) elevation. Pathological lens changes characteristic of high myopia include early cataractogenesis, overgrowth of lens, weakened zonules, and postoperative capsular contraction syndrome, possibly driven by inflammatory pathogenesis, etc. Dome-shaped macula and cilioretinal arteries are two newly identified protective factors for central vision of highly myopic patients. These patients also face risks of open-angle glaucoma and IOP spike following intraocular surgery. Morphologic alternations of optic nerve in high myopia can complicate early glaucoma detection, necessitating comprehensive examinations and close follow-up. Anatomically, thinner trabecular meshwork increases this risk; conversely lamina cribrosa defects may offer a fluid outlet, potentially mitigating the pressure. Notably, anxiety has emerged as the first recognized extra-ocular complication in high myopia, with an underlying inflammatory pathogenesis that connects visual stimulus, blood and brain. Conclusions: High myopia induces multiple ocular and potential mental health complications, underscoring the need to develop more effective strategies to improve both physical and emotional well-being of these patients, among which anti-inflammation might possibly represent a promising new target.
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Registered trials
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