ArticleResearch and practice in thrombosis and haemostasis2024
Thioredoxin-related transmembrane protein 1 negatively regulates coagulation and phosphatidylserine exposure.
Article in Research and practice in thrombosis and haemostasis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Five secreted platelet protein disulfide isomerases (PDIs) and 1 transmembrane PDI regulate platelet function and thrombosis. Thioredoxin-related transmembrane protein 1 (TMX1) was the first member of the PDI family found to negatively regulate platelet aggregation and platelet accumulation Objectives: To determine the effect of TMX1 on coagulation. Methods: TMX1 Results: TMX1 Conclusion: TMX1 decreases coagulation at the site of vascular injury and negatively regulates phosphatidylserine exposure on endothelial cells and platelets.
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