Evidence map›Paper›PMID 39036434›Full record

ArticleNeurotrauma reports2024

Association Between Traumatic Brain Injury and Cognitive Decline Among Middle-to-Older Aged Men in the Vietnam Era Twin Study of Aging.

Alexander Ivan B Posis, John E Alcaraz, Humberto Parada, Aladdin H Shadyab, Jeremy A Elman, Matthew S Panizzon, Chandra A Reynolds, Carol E Franz, William S Kremen, Linda K McEvoy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander Ivan B PosisHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
John E AlcarazSchool of Public Health, San Diego State University, San Diego, California, USA.
Humberto ParadaSchool of Public Health, San Diego State University, San Diego, California, USA.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.
Jeremy A ElmanDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Matthew S PanizzonDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Chandra A ReynoldsInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA.
Carol E FranzDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
William S KremenDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Linda K McEvoyHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, California, USA.

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
Research Education CoreU54CA132384 · NCI · SAN DIEGO STATE UNIVERSITY · PI CRIPPS, RICHARD MATTHEW, CROWE, SHEILA E. · 2008 to 2022
$20.7M
Research Education CoreU54CA132379 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARREDONDO, ELVA M, CROWE, SHEILA E. · 2008 to 2021
$16.1M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Plasma Proteomic Signatures for Alzheimer's Disease and Related DementiasRF1AG079149 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCEVOY, LINDA KATHLEEN, SHADYAB, ALADDIN · 2022 to 2022
$7.5M
San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOHN P. ELDER, PAUL E GILBERT · 2018 to 2026
$7.4M
Genetic Predictors, Transcriptomic Biomarkers, & Neurobiological Signatures of Resilience to Alzheimer's DiseaseR01AG064955 · NIA · UPSTATE MEDICAL UNIVERSITY · PI FENNEMA-NOTESTINE, CHRISTINE, GLATT, STEPHEN J · 2019 to 2023
$3.8M
Clarifying risk and protective factors for dementia with the Interplay of Genes and Environment in Multiple Studies (IGEMS) consortiumR01AG060470 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2018 to 2022
$3.6M
Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2M
Epigenetic Aging Biomarkers of Mild Cognitive Impairment, Alzheimer's Disease and Related Dementias, and Brain AgingRF1AG074345 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHADYAB, ALADDIN · 2021 to 2021
$2.1M
NCI NIH HHS K01 CA234317NCI NIH HHS U54 CA132379NCI NIH HHS U54 CA132384NIA NIH HHS K01 AG063805NIA NIH HHS P01 AG055367NIA NIH HHS P30 AG059299NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG060470NIA NIH HHS R01 AG064955NIA NIH HHS R01 AG076838NIA NIH HHS RF1 AG074345NIA NIH HHS RF1 AG079149NIA NIH HHS T32 AG058529
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is associated with increased risk of dementia. However, whether TBI is associated with greater cognitive decline over time in specific cognitive domains among older adults is not well understood. This prospective cohort study used data from 1476 male Vietnam Era Twin Study of Aging participants (average age at study entry = 57.9 years, range = 51-71 years; 97.6% non-Hispanic; 92.5% White) collected from 2003 to 2019, who had complete information on prior TBI. Participants completed a comprehensive neuropsychological assessment at up to three visits over up to a 12-year follow-up period during which they also self-reported their history of TBI. Multivariable, linear mixed-effects models were used to assess associations between TBI and cognitive performance trajectories. Effect measure modification by apolipoprotein E (

Indexed as

agingcognitionepidemiologyprospective cohorttraumatic brain injury

Identifiers

PMID39036434
PMCPMC11257108

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.