Evidence map›Paper›PMID 39036341›Full record

ReviewMedComm2024

The gut microbiota-brain axis in neurological disorders.

Mingming You, Nan Chen, Yuanyuan Yang, Lingjun Cheng, Hongzhang He, Yanhua Cai, Yating Liu, Haiyue Liu, Guolin Hong

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in MedComm, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07381374 (Study Protocol for a Randomized Controlled of Fecal Microbiota Transplantation Via Different Routes in Children With Moderate-to-Severe Autism Spectrum Disorder), which is not on this map. Cited by 65 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07381374 narecruitingnot on this mapstarted 2026, after this paper: background citation

Study Protocol for a Randomized Controlled of Fecal Microbiota Transplantation Via Different Routes in Children With Moderate-to-Severe Autism Spectrum Disorder

TypeinterventionalSponsorShenzhen Children's HospitalRan2026 to 2027Enrolled1ConditionsAutism Spectrum DisorderArmsctive FMT via Nasojejunal Tube (FMT-Upper GI), Active FMT via Colonoscopy and Transendoscopic Tube (FMT-Lower GI), Placebo via Sham Procedures (Sham-Control)
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Gut microbiota in health and disease.Molecular biomedicine · 2026
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mingming YouXiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Nan ChenMaster of Public Health School of Public Health Xiamen University Xiamen China.
Yuanyuan YangXiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Lingjun ChengXiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Hongzhang HeXiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Yanhua CaiMaster of Public Health School of Public Health Xiamen University Xiamen China.
Yating LiuXiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Haiyue LiuXiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.
Guolin HongXiamen Key Laboratory of Genetic Testing The Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University Xiamen China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as the microbiota-gut-brain axis (MGBA). The MGBA influences the host's nervous system development, emotional regulation, and cognitive function through neurotransmitters, immune modulation, and metabolic pathways. Factors like diet, lifestyle, genetics, and environment shape the gut microbiota composition together. Most research have explored how gut microbiota regulates host physiology and its potential in preventing and treating neurological disorders. However, the individual heterogeneity of gut microbiota, strains playing a dominant role in neurological diseases, and the interactions of these microbial metabolites with the central/peripheral nervous systems still need exploration. This review summarizes the potential role of gut microbiota in driving neurodevelopmental disorders (autism spectrum disorder and attention deficit/hyperactivity disorder), neurodegenerative diseases (Alzheimer's and Parkinson's disease), and mood disorders (anxiety and depression) in recent years and discusses the current clinical and preclinical gut microbe-based interventions, including dietary intervention, probiotics, prebiotics, and fecal microbiota transplantation. It also puts forward the current insufficient research on gut microbiota in neurological disorders and provides a framework for further research on neurological disorders.

Indexed as

Alzheimer's diseaseautismfecal microbiota transplantationgut microbiota–brain axisneurological disordersParkinson's diseaseprobiotics

Identifiers

PMID39036341
PMCPMC11260174

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.