Evidence map›Paper›PMID 39035820›Full record

ArticleResearch in pharmaceutical sciences2024

Spiroconjugated 1,2,3-triazolo[5,1-

Irina M Petrova, Sofya Iu Chebanova, Sergey L Khatsko, Tatyana A Kalinina, Dmitry V Zaitsev, Tatyana V Glukhareva

Abstract read
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Article in Research in pharmaceutical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Irina M PetrovaUral Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia.
Sofya Iu ChebanovaUral Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia.
Sergey L KhatskoUral Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia.
Tatyana A KalininaUral Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia.
Dmitry V ZaitsevUral Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia.
Tatyana V GlukharevaUral Federal University named after the first President of Russia B. N. Yeltsin, Yekaterinburg, 620026, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: One of the most important mechanisms of tissue regeneration is the high functional activity of cells, including proliferation. Currently, there are practically no effective skin cell activators on the pharmaceutical market. The purpose of this work was to demonstrate the stimulating effect of spiroconjugated 1,2,3-triazolo[5,1- Experimental approach: STT containing ointment for dermal application was made. To assess Findings/Results: The STT significantly increased the number of fibroblasts as well as the density and order of produced collagen fibers in the dermis during the wound healing process. As a result, a tissue was formed at the site of damage with the structure corresponding to normal skin. In addition, skin functions were restored, in particular mechanically. Conclusion and implications: The results suggested the stimulating effect of the STT on fibroblast activity and demonstrated its potential for skin regeneration.

Indexed as

1,2,3-Triazolo-1,3,4-thiadiazineCollagenFibroblastsKi-67Mast cellsSkin woundVimentin

Identifiers

PMID39035820
PMCPMC11257193

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.