Evidence map›Paper›PMID 39035770›Full record

ArticleJournal of the National Cancer Center2021

Significance of radiation esophagitis: Conditional survival assessment in patients with non-small cell lung cancer.

Hao Yu, Ka-On Lam, Michael D Green, Huanmei Wu, Li Yang, Weili Wang, Jianyue Jin, Chen Hu, Yang Wang, Shruti Jolly and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Center, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06958445 (The Efficacy of Sodium Alginate on Prevention of Oral Mucositis and Quality of Life for Patients With Breast Cancer Undergoing Adjuvant Radiotherapy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06958445 phase2enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

The Efficacy of Sodium Alginate on Prevention of Oral Mucositis and Quality of Life for Patients With Breast Cancer Undergoing Adjuvant Radiotherapy

TypeinterventionalSponsorTaipei City HospitalRan2024 to 2027Enrolled90ConditionsBreast CarcinomaArmsAlginos Oral Suspension
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hao YuBiomedical Engineering, Shenzhen Polytechnic, Shenzhen, China.
Ka-On LamDepartment of Clinical Oncology, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong, China.
Michael D GreenRadiation Oncology, Ann Arbor VA Health Care, Ann Arbor, MI, USA.
Huanmei WuBioHealth Informatics, School of Informatics and Computing, IUPUI, Indianapolis, IN, USA.
Li YangClinical Oncology Center, the University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
Weili WangUniversity Hospitals/Cleveland Medical Center, Seidman Cancer Center and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
Jianyue JinUniversity Hospitals/Cleveland Medical Center, Seidman Cancer Center and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
Chen HuSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yang WangBiomedical Engineering, Shenzhen Polytechnic, Shenzhen, China.
Shruti JollyRadiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Feng-Ming Spring KongDepartment of Clinical Oncology, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to examine the effect of radiation esophagitis (RE) and the dynamics of RE on subsequent survival in non-small cell lung cancer (NSCLC) patients who underwent radiotherapy. Experimental Design: Patients with NSCLC treated with fractionated thoracic radiotherapy enrolled in prospective trials were eligible. RE was graded prospectively according to Common Terminology Criteria for Adverse Events (CTCAE) v3.0 per protocol requirement weekly during-RT and 1 month after RT. This study applied conditional survival assessment which has advantage over traditional survival analysis as it assesses the survival from the event instead of from the baseline. Results: A total of 177 patients were eligible, with a median follow-up of 5 years. The presence of RE, the maximum RE grade, the evolution of RE and the onset timing of RE events were all correlated with subsequent survival. At all conditional time points, patients first presented with RE grade1 (initial RE1) had significant inferior subsequent survival (multivariable HRs median: 1.63, all Conclusion: This study comprehensively evaluated the impact of RE with conditional survival assessment and demonstrated that RE is associated with inferior survival in NSCLC patients treated with RT.

Indexed as

Conditional survivalNon-small cell lung cancerRadiation esophagitisRadiotherapy

Identifiers

PMID39035770
PMCPMC11256695

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.