Evidence map›Paper›PMID 39035576›Full record

ArticleJournal of biomedical optics2024

Deep learning-enabled high-speed, multi-parameter diffuse optical tomography.

Robin Dale, Biao Zheng, Felipe Orihuela-Espina, Nicholas Ross, Thomas D O'Sullivan, Scott Howard, Hamid Dehghani

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robin DaleUniversity of Birmingham, School of Computer Science, Medical Imaging Lab, Birmingham, United Kingdom.ORCID 0000-0001-8013-7768
Biao ZhengUniversity of Birmingham, School of Computer Science, Medical Imaging Lab, Birmingham, United Kingdom.ORCID 0009-0003-5740-3054
Felipe Orihuela-EspinaUniversity of Birmingham, School of Computer Science, Medical Imaging Lab, Birmingham, United Kingdom.ORCID 0000-0001-8963-7283
Nicholas RossUniversity of Notre Dame, Department of Electrical Engineering, Notre Dame, Indiana, United States.ORCID 0009-0008-5282-3099
Thomas D O'SullivanUniversity of Notre Dame, Department of Electrical Engineering, Notre Dame, Indiana, United States.ORCID 0000-0001-8662-5121
Scott HowardUniversity of Notre Dame, Department of Electrical Engineering, Notre Dame, Indiana, United States.
Hamid DehghaniUniversity of Birmingham, School of Computer Science, Medical Imaging Lab, Birmingham, United Kingdom.ORCID 0000-0003-4117-0412

Funding

Next generation deep tissue quantitative optical imagingR01EB029595 · NIBIB · UNIVERSITY OF NOTRE DAME · PI OSULLIVAN, THOMAS D · 2021 to 2024
$1.9M
NIBIB NIH HHS R01 EB029595
6 · The paper itself

Abstract

Significance: Frequency-domain diffuse optical tomography (FD-DOT) could enhance clinical breast tumor characterization. However, conventional diffuse optical tomography (DOT) image reconstruction algorithms require case-by-case expert tuning and are too computationally intensive to provide feedback during a scan. Deep learning (DL) algorithms front-load computational and tuning costs, enabling high-speed, high-fidelity FD-DOT. Aim: We aim to demonstrate a simultaneous reconstruction of three-dimensional absorption and reduced scattering coefficients using DL-FD-DOT, with a view toward real-time imaging with a handheld probe. Approach: A DL model was trained to solve the DOT inverse problem using a realistically simulated FD-DOT dataset emulating a handheld probe for human breast imaging and tested using both synthetic and experimental data. Results: Over a test set of 300 simulated tissue phantoms for absorption and scattering reconstructions, the DL-DOT model reduced the root mean square error by Conclusions: There is clinical potential for real-time functional imaging of human breast tissue using DL and FD-DOT.

Indexed as

AlgorithmsBreast NeoplasmsDeep LearningImage Processing, Computer-AssistedPhantoms, ImagingTomography, OpticalBreastFemaleHumansImaging, Three-Dimensionalbreast imagingdeep learningdiffuse optical tomographyfrequency domainscattering

Identifiers

PMID39035576
PMCPMC11259453

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.